2coz

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[[Image:2coz.png|left|200px]]
 
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==Solution structure of the CAP-Gly domain in human centrosome-associated protein CAP350==
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The line below this paragraph, containing "STRUCTURE_2coz", creates the "Structure Box" on the page.
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<StructureSection load='2coz' size='340' side='right'caption='[[2coz]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2coz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2COZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2COZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2coz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2coz OCA], [https://pdbe.org/2coz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2coz RCSB], [https://www.ebi.ac.uk/pdbsum/2coz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2coz ProSAT], [https://www.topsan.org/Proteins/RSGI/2coz TOPSAN]</span></td></tr>
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{{STRUCTURE_2coz| PDB=2coz | SCENE= }}
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</table>
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== Function ==
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===Solution structure of the CAP-Gly domain in human centrosome-associated protein CAP350===
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[https://www.uniprot.org/uniprot/CE350_HUMAN CE350_HUMAN] Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity.<ref>PMID:15615782</ref> <ref>PMID:16314388</ref> <ref>PMID:17878239</ref> <ref>PMID:18412956</ref> <ref>PMID:19052644</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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[[2coz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2COZ OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/2coz_consurf.spt"</scriptWhenChecked>
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==See Also==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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*[[CAP-Gly domain|CAP-Gly domain]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2coz ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Inoue, M.]]
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[[Category: Large Structures]]
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[[Category: Kigawa, T.]]
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[[Category: Inoue M]]
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[[Category: Koshiba, S.]]
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[[Category: Kigawa T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Koshiba S]]
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[[Category: Saito, K.]]
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[[Category: Saito K]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Cytoskeleton associated protein]]
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[[Category: Microtubule binding]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Protein binding]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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Current revision

Solution structure of the CAP-Gly domain in human centrosome-associated protein CAP350

PDB ID 2coz

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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