3t3s

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[[Image:3t3s.png|left|200px]]
 
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==Human Cytochrome P450 2A13 in complex with Pilocarpine==
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The line below this paragraph, containing "STRUCTURE_3t3s", creates the "Structure Box" on the page.
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<StructureSection load='3t3s' size='340' side='right'caption='[[3t3s]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3t3s]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T3S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9PL:(3S,4R)-3-ETHYL-4-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]DIHYDROFURAN-2(3H)-ONE'>9PL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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{{STRUCTURE_3t3s| PDB=3t3s | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t3s OCA], [https://pdbe.org/3t3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t3s RCSB], [https://www.ebi.ac.uk/pdbsum/3t3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t3s ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CP2AD_HUMAN CP2AD_HUMAN] Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.<ref>PMID:18779312</ref>
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===Human Cytochrome P450 2A13 in complex with Pilocarpine===
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22051186 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22051186}}
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==About this Structure==
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[[3t3s]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T3S OCA].
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==Reference==
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<ref group="xtra">PMID:022051186</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Unspecific monooxygenase]]
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[[Category: Large Structures]]
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[[Category: DeVore, N M.]]
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[[Category: DeVore NM]]
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[[Category: Scott, E E.]]
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[[Category: Scott EE]]
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[[Category: Cyp2a13]]
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[[Category: Cytochrome p450 2a13]]
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[[Category: Drug metabolism]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Heme protein]]
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[[Category: Membrane]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase]]
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[[Category: P450 2a13]]
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[[Category: Xenobiotic metabolism]]
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Current revision

Human Cytochrome P450 2A13 in complex with Pilocarpine

PDB ID 3t3s

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