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| - | [[Image:3ui2.png|left|200px]] | |
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| - | <!--
| + | ==Crystal structure of the cpSRP54 tail bound to cpSRP43== |
| - | The line below this paragraph, containing "STRUCTURE_3ui2", creates the "Structure Box" on the page.
| + | <StructureSection load='3ui2' size='340' side='right'caption='[[3ui2]], [[Resolution|resolution]] 3.18Å' scene=''> |
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet)
| + | == Structural highlights == |
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
| + | <table><tr><td colspan='2'>[[3ui2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UI2 FirstGlance]. <br> |
| - | or leave the SCENE parameter empty for the default display.
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.178Å</td></tr> |
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| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ui2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ui2 OCA], [https://pdbe.org/3ui2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ui2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ui2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ui2 ProSAT]</span></td></tr> |
| - | {{STRUCTURE_3ui2| PDB=3ui2 | SCENE= }}
| + | </table> |
| - | | + | == Function == |
| - | ===Crystal structure of the cpSRP54 tail bound to cpSRP43===
| + | [https://www.uniprot.org/uniprot/SR43C_ARATH SR43C_ARATH] Component of the chloroplast signal recognition particle pathway. Required for post-translational targeting of proteins into the tylakoid membrane but seems to be dispensable for co-translational targeting with a translating ribosome present. May be able to function independently of cpFTSY and FFC/cpSRP54 in targeting LHCPs to the thylakoids. Acts as a highly specific chaperone for LHCPs, preventing aggregation and being able to dissolve aggregates.<ref>PMID:9878634</ref> <ref>PMID:10480939</ref> <ref>PMID:15292240</ref> <ref>PMID:17513500</ref> <ref>PMID:20498370</ref> |
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| - | <!-- | + | |
| - | The line below this paragraph, {{ABSTRACT_PUBMED_22231402}}, adds the Publication Abstract to the page
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| - | (as it appears on PubMed at http://www.pubmed.gov), where 22231402 is the PubMed ID number.
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| - | -->
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| - | {{ABSTRACT_PUBMED_22231402}}
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| - | | + | |
| - | ==About this Structure== | + | |
| - | [[3ui2]] is a 2 chain structure of [[Signal recognition particle protein]] with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UI2 OCA]. | + | |
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| | ==See Also== | | ==See Also== |
| - | *[[Signal recognition particle protein|Signal recognition particle protein]] | + | *[[Signal recognition particle 3D structures|Signal recognition particle 3D structures]] |
| - | | + | == References == |
| - | ==Reference== | + | <references/> |
| - | <ref group="xtra">PMID:022231402</ref><references group="xtra"/> | + | __TOC__ |
| | + | </StructureSection> |
| | [[Category: Arabidopsis thaliana]] | | [[Category: Arabidopsis thaliana]] |
| - | [[Category: Holdermann, I.]] | + | [[Category: Large Structures]] |
| - | [[Category: Sinning, I.]] | + | [[Category: Holdermann I]] |
| - | [[Category: Wild, K.]] | + | [[Category: Sinning I]] |
| - | [[Category: Ankyrin repeat]] | + | [[Category: Wild K]] |
| - | [[Category: Aromatic cage]]
| + | |
| - | [[Category: Chloroplast]]
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| - | [[Category: Chromodomain]]
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| - | [[Category: Membrane protein chaperone]]
| + | |
| - | [[Category: Protein targeting]]
| + | |
| - | [[Category: Signal recognition particle]]
| + | |
| - | [[Category: Transport protein]]
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| Structural highlights
Function
SR43C_ARATH Component of the chloroplast signal recognition particle pathway. Required for post-translational targeting of proteins into the tylakoid membrane but seems to be dispensable for co-translational targeting with a translating ribosome present. May be able to function independently of cpFTSY and FFC/cpSRP54 in targeting LHCPs to the thylakoids. Acts as a highly specific chaperone for LHCPs, preventing aggregation and being able to dissolve aggregates.[1] [2] [3] [4] [5]
See Also
References
- ↑ Klimyuk VI, Persello-Cartieaux F, Havaux M, Contard-David P, Schuenemann D, Meiherhoff K, Gouet P, Jones JD, Hoffman NE, Nussaume L. A chromodomain protein encoded by the arabidopsis CAO gene is a plant-specific component of the chloroplast signal recognition particle pathway that is involved in LHCP targeting. Plant Cell. 1999 Jan;11(1):87-99. PMID:9878634
- ↑ Tu CJ, Schuenemann D, Hoffman NE. Chloroplast FtsY, chloroplast signal recognition particle, and GTP are required to reconstitute the soluble phase of light-harvesting chlorophyll protein transport into thylakoid membranes. J Biol Chem. 1999 Sep 17;274(38):27219-24. PMID:10480939
- ↑ Goforth RL, Peterson EC, Yuan J, Moore MJ, Kight AD, Lohse MB, Sakon J, Henry RL. Regulation of the GTPase cycle in post-translational signal recognition particle-based protein targeting involves cpSRP43. J Biol Chem. 2004 Oct 8;279(41):43077-84. Epub 2004 Aug 2. PMID:15292240 doi:http://dx.doi.org/10.1074/jbc.M401600200
- ↑ Tzvetkova-Chevolleau T, Hutin C, Noel LD, Goforth R, Carde JP, Caffarri S, Sinning I, Groves M, Teulon JM, Hoffman NE, Henry R, Havaux M, Nussaume L. Canonical signal recognition particle components can be bypassed for posttranslational protein targeting in chloroplasts. Plant Cell. 2007 May;19(5):1635-48. Epub 2007 May 18. PMID:17513500 doi:http://dx.doi.org/10.1105/tpc.106.048959
- ↑ Falk S, Sinning I. cpSRP43 is a novel chaperone specific for light-harvesting chlorophyll a,b-binding proteins. J Biol Chem. 2010 Jul 9;285(28):21655-61. doi: 10.1074/jbc.C110.132746. Epub 2010, May 24. PMID:20498370 doi:http://dx.doi.org/10.1074/jbc.C110.132746
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