2da7
From Proteopedia
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| - | [[Image:2da7.jpg|left|200px]]<br /><applet load="2da7" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2da7" /> | ||
| - | '''Solution structure of the homeobox domain of Zinc finger homeobox protein 1b (Smad interacting protein 1)'''<br /> | ||
| - | == | + | ==Solution structure of the homeobox domain of Zinc finger homeobox protein 1b (Smad interacting protein 1)== |
| - | + | <StructureSection load='2da7' size='340' side='right'caption='[[2da7]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[2da7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DA7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DA7 FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2da7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2da7 OCA], [https://pdbe.org/2da7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2da7 RCSB], [https://www.ebi.ac.uk/pdbsum/2da7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2da7 ProSAT], [https://www.topsan.org/Proteins/RSGI/2da7 TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/ZEB2_HUMAN ZEB2_HUMAN] Mowat-Wilson syndrome due to monosomy 2q22;Mowat-Wilson syndrome due to a ZEB2 point mutation. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ZEB2_HUMAN ZEB2_HUMAN] Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212).<ref>PMID:16061479</ref> <ref>PMID:20516212</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/2da7_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2da7 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Inoue | + | [[Category: Inoue M]] |
| - | [[Category: Kigawa | + | [[Category: Kigawa T]] |
| - | [[Category: Koshiba | + | [[Category: Koshiba S]] |
| - | [[Category: Ohnishi | + | [[Category: Ohnishi S]] |
| - | + | [[Category: Sato M]] | |
| - | [[Category: Sato | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
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Current revision
Solution structure of the homeobox domain of Zinc finger homeobox protein 1b (Smad interacting protein 1)
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Categories: Homo sapiens | Large Structures | Inoue M | Kigawa T | Koshiba S | Ohnishi S | Sato M | Yokoyama S
