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4avm
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4avm is ON HOLD Authors: Allerston, C.K., Krojer, T., Cooper, C.D.O., Vollmar, M., Arrowsmith, C.H., Edwards, A., Bountra, C., VonDelft, F., Gileadi...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the N-BAR domain of human bridging integrator 2.== | |
| - | + | <StructureSection load='4avm' size='340' side='right'caption='[[4avm]], [[Resolution|resolution]] 1.91Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4avm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AVM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4avm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4avm OCA], [https://pdbe.org/4avm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4avm RCSB], [https://www.ebi.ac.uk/pdbsum/4avm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4avm ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BIN2_HUMAN BIN2_HUMAN] Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.<ref>PMID:23285027</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Allerston CK]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Cooper CDO]] | ||
| + | [[Category: Edwards A]] | ||
| + | [[Category: Gileadi O]] | ||
| + | [[Category: Krojer T]] | ||
| + | [[Category: Vollmar M]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Crystal structure of the N-BAR domain of human bridging integrator 2.
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Categories: Homo sapiens | Large Structures | Allerston CK | Arrowsmith CH | Bountra C | Cooper CDO | Edwards A | Gileadi O | Krojer T | Vollmar M | Von Delft F
