4feg

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'''Unreleased structure'''
 
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The entry 4feg is ON HOLD
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==High-resolution structure of pyruvate oxidase in complex with reaction intermediate 2-hydroxyethyl-thiamin diphosphate carbanion-enamine, crystal A==
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<StructureSection load='4feg' size='340' side='right'caption='[[4feg]], [[Resolution|resolution]] 1.09&Aring;' scene=''>
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Authors: Meyer, D., Neumann, P., Koers, E., Sjuts, H., Luedtke, S., Sheldrick, G. M., Ficner, R., Tittmann, K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4feg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactiplantibacillus_plantarum_JDM1 Lactiplantibacillus plantarum JDM1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FEG FirstGlance]. <br>
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Description: Unexpected tautomeric equilibria of the carbanion-enamine intermediate in pyruvate oxidase highlight unrecognized chemical versatility of the thiamin cofactor
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.09&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>, <scene name='pdbligand=TDM:2-[(2E)-3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-(1-HYDROXYETHYLIDENE)-4-METHYL-2,3-DIHYDRO-1,3-THIAZOL-5-YL]ETHYL+TRIHYDROGEN+DIPHOSPHATE'>TDM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4feg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4feg OCA], [https://pdbe.org/4feg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4feg RCSB], [https://www.ebi.ac.uk/pdbsum/4feg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4feg ProSAT]</span></td></tr>
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</table>
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__TOC__
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</StructureSection>
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[[Category: Lactiplantibacillus plantarum JDM1]]
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[[Category: Large Structures]]
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[[Category: Ficner R]]
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[[Category: Koers E]]
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[[Category: Luedtke S]]
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[[Category: Meyer D]]
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[[Category: Neumann P]]
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[[Category: Sheldrick GM]]
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[[Category: Sjuts H]]
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[[Category: Tittmann K]]

Current revision

High-resolution structure of pyruvate oxidase in complex with reaction intermediate 2-hydroxyethyl-thiamin diphosphate carbanion-enamine, crystal A

PDB ID 4feg

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