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4few

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'''Unreleased structure'''
 
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The entry 4few is ON HOLD
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==Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP2==
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<StructureSection load='4few' size='340' side='right'caption='[[4few]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4few]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii_AYE Acinetobacter baumannii AYE]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FEW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KAN:KANAMYCIN+A'>KAN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PP2:1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE'>PP2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4few FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4few OCA], [https://pdbe.org/4few PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4few RCSB], [https://www.ebi.ac.uk/pdbsum/4few PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4few ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B0VD92_ACIBY B0VD92_ACIBY]
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Authors: Stogios, P.J., Evdokimova, E., Wawrzak, Z., Minasov, G., Egorova, O., Di Leo, R., Shakya, T., Spanogiannopoulos, P., Wright, G.D., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
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==See Also==
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*[[Phosphotransferase 3D structures|Phosphotransferase 3D structures]]
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Description: Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP2
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__TOC__
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</StructureSection>
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[[Category: Acinetobacter baumannii AYE]]
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[[Category: Large Structures]]
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[[Category: Anderson WF]]
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[[Category: Di Leo R]]
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[[Category: Egorova O]]
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[[Category: Evdokimova E]]
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[[Category: Minasov G]]
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[[Category: Savchenko A]]
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[[Category: Shakya T]]
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[[Category: Spanogiannopoulos P]]
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[[Category: Stogios PJ]]
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[[Category: Wawrzak Z]]
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[[Category: Wright GD]]

Current revision

Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP2

PDB ID 4few

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