3suv

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[[Image:3suv.jpg|left|200px]]
 
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==Crystal structure of beta-hexosaminidase from Paenibacillus sp. TS12 in complex with NHAc-DNJ==
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The line below this paragraph, containing "STRUCTURE_3suv", creates the "Structure Box" on the page.
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<StructureSection load='3suv' size='340' side='right'caption='[[3suv]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3suv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Paenibacillus_sp._TS12 Paenibacillus sp. TS12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SUV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NOK:2-ACETAMIDO-1,2-DIDEOXYNOJIRMYCIN'>NOK</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3suv| PDB=3suv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3suv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3suv OCA], [https://pdbe.org/3suv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3suv RCSB], [https://www.ebi.ac.uk/pdbsum/3suv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3suv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/D2KW09_9BACL D2KW09_9BACL]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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One useful methodology that has been used to give insight into how chemically synthesized inhibitors bind to enzymes and the reasons underlying their potency is crystallographic studies of inhibitor-enzyme complexes. Presented here is the X-ray structural analysis of a representative family 20 exo-beta-N-acetylhexosaminidase in complex with various known classes of inhibitor of these types of enzymes, which highlights how different inhibitor classes can inhibit the same enzyme. This study will aid in the future development of inhibitors of not only exo-beta-N-acetylhexosaminidases but also other types of glycoside hydrolases.
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===Crystal structure of beta-hexosaminidase from Paenibacillus sp. TS12 in complex with NHAc-DNJ===
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Gaining insight into the inhibition of glycoside hydrolase family 20 exo-beta-N-acetylhexosaminidases using a structural approach.,Sumida T, Stubbs KA, Ito M, Yokoyama S Org Biomol Chem. 2012 Apr 7;10(13):2607-12. Epub 2012 Feb 27. PMID:22367352<ref>PMID:22367352</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3suv" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22367352}}, adds the Publication Abstract to the page
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*[[Beta-Hexosaminidase|Beta-Hexosaminidase]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22367352 is the PubMed ID number.
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*[[Beta-Hexosaminidase 3D structures|Beta-Hexosaminidase 3D structures]]
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*[[Beta-N-acetylhexosaminidase 3D structures|Beta-N-acetylhexosaminidase 3D structures]]
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{{ABSTRACT_PUBMED_22367352}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3suv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Paenibacillus Paenibacillus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SUV OCA].
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</StructureSection>
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[[Category: Large Structures]]
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==Reference==
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[[Category: Paenibacillus sp. TS12]]
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<ref group="xtra">PMID:022367352</ref><references group="xtra"/>
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[[Category: Sumida T]]
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[[Category: Beta-N-acetylhexosaminidase]]
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[[Category: Yokoyama S]]
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[[Category: Paenibacillus]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Sumida, T.]]
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[[Category: Yokoyama, S.]]
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[[Category: Carbohydrate/sugar binding]]
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[[Category: Hydrolase]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Tim barrel]]
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Current revision

Crystal structure of beta-hexosaminidase from Paenibacillus sp. TS12 in complex with NHAc-DNJ

PDB ID 3suv

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