4ehr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:03, 1 March 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4ehr.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide==
-
The line below this paragraph, containing "STRUCTURE_4ehr", creates the "Structure Box" on the page.
+
<StructureSection load='4ehr' size='340' side='right'caption='[[4ehr]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[4ehr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EHR FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0Q5:4-[5-BUTYL-3-(HYDROXYMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL]-3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YLCARBONYL)-N-{[2-(TRIMETHYLSILYL)ETHYL]SULFONYL}BENZAMIDE'>0Q5</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
-
{{STRUCTURE_4ehr| PDB=4ehr | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ehr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehr OCA], [https://pdbe.org/4ehr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ehr RCSB], [https://www.ebi.ac.uk/pdbsum/4ehr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ehr ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
-
===Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide===
+
==See Also==
-
 
+
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_22608393}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 22608393 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_22608393}}
+
-
 
+
-
==About this Structure==
+
-
[[4ehr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHR OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:022608393</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Banfi, P.]]
+
[[Category: Large Structures]]
-
[[Category: Borzilleri, R M.]]
+
[[Category: Banfi P]]
-
[[Category: Cai, Z.]]
+
[[Category: Borzilleri RM]]
-
[[Category: Galvani, A.]]
+
[[Category: Cai Z]]
-
[[Category: Lippy, J.]]
+
[[Category: Galvani A]]
-
[[Category: Lombardo, L J.]]
+
[[Category: Lippy J]]
-
[[Category: Menichincheri, M.]]
+
[[Category: Lombardo LJ]]
-
[[Category: Modugno, M.]]
+
[[Category: Menichincheri M]]
-
[[Category: Naglich, J.]]
+
[[Category: Modugno M]]
-
[[Category: Penhallow, B.]]
+
[[Category: Naglich J]]
-
[[Category: Perez, H L.]]
+
[[Category: Penhallow B]]
-
[[Category: Sack, J.]]
+
[[Category: Perez HL]]
-
[[Category: Schmidt, R J.]]
+
[[Category: Sack J]]
-
[[Category: Schroeder, G M.]]
+
[[Category: Schmidt RJ]]
-
[[Category: Tebben, A.]]
+
[[Category: Schroeder GM]]
-
[[Category: Wei, D.]]
+
[[Category: Tebben A]]
-
[[Category: Yan, C.]]
+
[[Category: Wei D]]
-
[[Category: Zhang, L.]]
+
[[Category: Yan C]]
-
[[Category: Apoptosis]]
+
[[Category: Zhang L]]
-
[[Category: Bcl-2 family]]
+
-
[[Category: Programmed cell death]]
+

Current revision

Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide

PDB ID 4ehr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ehr"
Personal tools