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3u2m

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[[Image:3u2m.jpg|left|200px]]
 
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==Crystal structure of human ALR mutant C142/145S==
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The line below this paragraph, containing "STRUCTURE_3u2m", creates the "Structure Box" on the page.
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<StructureSection load='3u2m' size='340' side='right'caption='[[3u2m]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3u2m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U2M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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{{STRUCTURE_3u2m| PDB=3u2m | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2m OCA], [https://pdbe.org/3u2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u2m RCSB], [https://www.ebi.ac.uk/pdbsum/3u2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u2m ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ALR_HUMAN ALR_HUMAN] Congenital cataract - progressive muscular hypotonia - hearing loss - developmental delay. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/ALR_HUMAN ALR_HUMAN] Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen.<ref>PMID:19397338</ref> <ref>PMID:23186364</ref> <ref>PMID:20593814</ref> <ref>PMID:21383138</ref> <ref>PMID:22224850</ref> Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration.<ref>PMID:19397338</ref> <ref>PMID:23186364</ref> <ref>PMID:20593814</ref> <ref>PMID:21383138</ref> <ref>PMID:22224850</ref>
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===Crystal structure of human ALR mutant C142/145S===
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==See Also==
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*[[Sulfhydryl oxidase 3D structures|Sulfhydryl oxidase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22224850}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22224850 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22224850}}
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==About this Structure==
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[[3u2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2M OCA].
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==Reference==
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<ref group="xtra">PMID:022224850</ref><ref group="xtra">PMID:021383138</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Thiol oxidase]]
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[[Category: Large Structures]]
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[[Category: Banci, L.]]
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[[Category: Banci L]]
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[[Category: Bertini, I.]]
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[[Category: Bertini I]]
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[[Category: Calderone, V.]]
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[[Category: Calderone V]]
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[[Category: Cefaro, C.]]
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[[Category: Cefaro C]]
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[[Category: Ciofi-Baffoni, S.]]
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[[Category: Ciofi-Baffoni S]]
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[[Category: Gallo, A.]]
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[[Category: Gallo A]]
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[[Category: Alr]]
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[[Category: Fad]]
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[[Category: Flavin]]
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[[Category: Flavoprotein]]
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[[Category: Sulfhydryl oxidase]]
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Current revision

Crystal structure of human ALR mutant C142/145S

PDB ID 3u2m

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