3s86

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[[Image:3s86.jpg|left|200px]]
 
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==Crystal Structure of TM0159 with bound IMP==
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The line below this paragraph, containing "STRUCTURE_3s86", creates the "Structure Box" on the page.
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<StructureSection load='3s86' size='340' side='right'caption='[[3s86]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3s86]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S86 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3s86| PDB=3s86 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s86 OCA], [https://pdbe.org/3s86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s86 RCSB], [https://www.ebi.ac.uk/pdbsum/3s86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s86 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IXTPA_THEMA IXTPA_THEMA] Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.[HAMAP-Rule:MF_01405]
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===Crystal Structure of TM0159 with bound IMP===
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==See Also==
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*[[Nucleoside triphosphatase|Nucleoside triphosphatase]]
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*[[Sandbox 30008|Sandbox 30008]]
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==About this Structure==
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__TOC__
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[[3s86]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S86 OCA].
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</StructureSection>
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[[Category: Nucleoside-triphosphatase]]
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[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: Awwad, K.]]
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[[Category: Awwad K]]
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[[Category: Desai, A.]]
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[[Category: Desai A]]
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[[Category: Smith, C.]]
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[[Category: Smith C]]
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[[Category: Sommerhalter, M.]]
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[[Category: Sommerhalter M]]
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[[Category: Hydrolase]]
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[[Category: Long twisted beta strand covered by two lobe]]
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[[Category: Non-canonical nucleoside triphosphatase]]
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Current revision

Crystal Structure of TM0159 with bound IMP

PDB ID 3s86

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OCA

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