4eag

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:46, 8 November 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4eag.jpg|left|200px]]
 
-
<!--
+
==Co-crystal structure of an chimeric AMPK core with ATP==
-
The line below this paragraph, containing "STRUCTURE_4eag", creates the "Structure Box" on the page.
+
<StructureSection load='4eag' size='340' side='right'caption='[[4eag]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[4eag]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EAG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EAG FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.701&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
-
{{STRUCTURE_4eag| PDB=4eag | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eag OCA], [https://pdbe.org/4eag PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eag RCSB], [https://www.ebi.ac.uk/pdbsum/4eag PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eag ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/O18645_DROME O18645_DROME]
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The energy sensor AMP-activated protein kinase (AMPK) is a heterotrimeric complex that is allosterically activated by AMP binding to the gamma subunit. Cocrystal structures of the mammalian AMPK core reveal occlusion of nucleotide-binding site 3 of the gamma subunit in the presence of ATP. However, site 3 is occupied in the presence of AMP. Mutagenesis studies indicate that sites 3 and 4 are important for AMPK allosteric activation.
-
===Co-crystal structure of an chimeric AMPK core with ATP===
+
AMP-activated protein kinase undergoes nucleotide-dependent conformational changes.,Chen L, Wang J, Zhang YY, Yan SF, Neumann D, Schlattner U, Wang ZX, Wu JW Nat Struct Mol Biol. 2012 Jun 3;19(7):716-8. doi: 10.1038/nsmb.2319. PMID:22659875<ref>PMID:22659875</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 4eag" style="background-color:#fffaf0;"></div>
-
==About this Structure==
+
==See Also==
-
[[4eag]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EAG OCA].
+
*[[AMP-activated protein kinase 3D structures|AMP-activated protein kinase 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
 +
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
-
[[Category: Chen, L.]]
+
[[Category: Chen L]]
-
[[Category: Neumann, D.]]
+
[[Category: Neumann D]]
-
[[Category: Schlattner, U.]]
+
[[Category: Schlattner U]]
-
[[Category: Wang, J.]]
+
[[Category: Wang J]]
-
[[Category: Wang, Z X.]]
+
[[Category: Wang Z-X]]
-
[[Category: Wu, J W.]]
+
[[Category: Wu J-W]]
-
[[Category: Yan, S F.]]
+
[[Category: Yan SF]]
-
[[Category: Zhang, Y Y.]]
+
[[Category: Zhang Y-Y]]
-
[[Category: Ampk]]
+
-
[[Category: Transferase]]
+

Current revision

Co-crystal structure of an chimeric AMPK core with ATP

PDB ID 4eag

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4eag"
Personal tools