4ejj

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[[Image:4ejj.jpg|left|200px]]
 
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==Human Cytochrome P450 2A6 in complex with nicotine==
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The line below this paragraph, containing "STRUCTURE_4ejj", creates the "Structure Box" on the page.
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<StructureSection load='4ejj' size='340' side='right'caption='[[4ejj]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4ejj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EJJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NCT:(S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE'>NCT</scene></td></tr>
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{{STRUCTURE_4ejj| PDB=4ejj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ejj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ejj OCA], [https://pdbe.org/4ejj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ejj RCSB], [https://www.ebi.ac.uk/pdbsum/4ejj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ejj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CP2A6_HUMAN CP2A6_HUMAN] Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.<ref>PMID:1889415</ref> <ref>PMID:1944238</ref> <ref>PMID:11695850</ref> <ref>PMID:16086027</ref> <ref>PMID:17125252</ref> <ref>PMID:18779312</ref>
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===Human Cytochrome P450 2A6 in complex with nicotine===
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[4ejj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJJ OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Unspecific monooxygenase]]
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[[Category: Large Structures]]
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[[Category: DeVore, N M.]]
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[[Category: DeVore NM]]
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[[Category: Scott, E E.]]
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[[Category: Scott EE]]
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[[Category: Cytochrome p450 2a6]]
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[[Category: Drug metabolism]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Heme protein]]
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[[Category: Membrane]]
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[[Category: Monoxygenase]]
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[[Category: Oxidoreductase]]
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[[Category: P450 2a6]]
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[[Category: Xenobiotic metabolism]]
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Current revision

Human Cytochrome P450 2A6 in complex with nicotine

PDB ID 4ejj

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