1y7w

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[[Image:1y7w.png|left|200px]]
 
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==Crystal structure of a halotolerant carbonic anhydrase from Dunaliella salina==
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The line below this paragraph, containing "STRUCTURE_1y7w", creates the "Structure Box" on the page.
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<StructureSection load='1y7w' size='340' side='right'caption='[[1y7w]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1y7w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dunaliella_salina Dunaliella salina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y7W FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1y7w| PDB=1y7w | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7w OCA], [https://pdbe.org/1y7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y7w RCSB], [https://www.ebi.ac.uk/pdbsum/1y7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7w ProSAT], [https://www.topsan.org/Proteins/ISPC/1y7w TOPSAN]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y7/1y7w_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y7w ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Protein molecular adaptation to drastically shifting salinities was studied in dCA II, an alpha-type carbonic anhydrase (EC 4.2.1.1) from the exceptionally salt-tolerant unicellular green alga Dunaliella salina. The salt-inducible, extracellular dCA II is highly salt-tolerant and thus differs from its mesophilic homologs. The crystal structure of dCA II, determined at 1.86-A resolution, is globally similar to other alpha-type carbonic anhydrases except for two extended alpha-helices and an added Na-binding loop. Its unusual electrostatic properties include a uniformly negative surface electrostatic potential of lower magnitude than that observed in the highly acidic halophilic proteins and an exceptionally low positive potential at a site adjoining the catalytic Zn(2+) compared with mesophilic homologs. The halotolerant dCA II also differs from typical halophilic proteins in retaining conformational stability and solubility in low to high salt concentrations. The crucial role of electrostatic features in dCA II halotolerance is strongly supported by the ability to predict the unanticipated halotolerance of the murine CA XIV isozyme, which was confirmed biochemically. A proposal for the functional significance of the halotolerance of CA XIV in the kidney is presented.
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===Crystal structure of a halotolerant carbonic anhydrase from Dunaliella salina===
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Three-dimensional structure of a halotolerant algal carbonic anhydrase predicts halotolerance of a mammalian homolog.,Premkumar L, Greenblatt HM, Bageshwar UK, Savchenko T, Gokhman I, Sussman JL, Zamir A Proc Natl Acad Sci U S A. 2005 May 24;102(21):7493-8. Epub 2005 May 13. PMID:15894606<ref>PMID:15894606</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1y7w" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15894606 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15894606}}
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==About this Structure==
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[[1y7w]] is a 2 chain structure of [[Carbonic anhydrase]] with sequence from [http://en.wikipedia.org/wiki/Dunaliella_salina Dunaliella salina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7W OCA].
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==See Also==
==See Also==
*[[Carbonic anhydrase|Carbonic anhydrase]]
*[[Carbonic anhydrase|Carbonic anhydrase]]
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*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:015894606</ref><references group="xtra"/>
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<references/>
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[[Category: Carbonate dehydratase]]
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__TOC__
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</StructureSection>
[[Category: Dunaliella salina]]
[[Category: Dunaliella salina]]
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[[Category: Bageshwar, U K.]]
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[[Category: Large Structures]]
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[[Category: Gokhman, I.]]
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[[Category: Bageshwar UK]]
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[[Category: Greenblatt, H M.]]
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[[Category: Gokhman I]]
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[[Category: ISPC, Israel Structural Proteomics Center.]]
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[[Category: Greenblatt HM]]
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[[Category: Premkumar, L.]]
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[[Category: Premkumar L]]
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[[Category: Savchenko, T.]]
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[[Category: Savchenko T]]
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[[Category: Sussman, J L.]]
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[[Category: Sussman JL]]
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[[Category: Zamir, A.]]
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[[Category: Zamir A]]
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[[Category: Algal carbonic anhydrase]]
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[[Category: Alpha-type carbonic anhydrase]]
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[[Category: Anion tolerance]]
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[[Category: Dca ii]]
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[[Category: Dunaliella salina carbonic anhydrase]]
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[[Category: Haltolerant protein]]
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[[Category: ISPC]]
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[[Category: Israel Structural Proteomics Center]]
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[[Category: Lyase]]
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[[Category: Salt tolerant protein]]
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[[Category: Structural genomic]]
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[[Category: Zinc enzyme]]
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Current revision

Crystal structure of a halotolerant carbonic anhydrase from Dunaliella salina

PDB ID 1y7w

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