This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1wsp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1wsp" [edit=sysop:move=sysop])
Current revision (13:33, 13 March 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1wsp.png|left|200px]]
 
-
<!--
+
==Crystal structure of axin dix domain==
-
The line below this paragraph, containing "STRUCTURE_1wsp", creates the "Structure Box" on the page.
+
<StructureSection load='1wsp' size='340' side='right'caption='[[1wsp]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1wsp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WSP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WSP FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
-
{{STRUCTURE_1wsp| PDB=1wsp | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wsp OCA], [https://pdbe.org/1wsp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wsp RCSB], [https://www.ebi.ac.uk/pdbsum/1wsp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wsp ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/AXIN1_RAT AXIN1_RAT] Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. Also facilitates the phosphorylation of APC by GSK3B. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ws/1wsp_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wsp ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal structure of axin dix domain===
+
==See Also==
-
 
+
*[[Axin|Axin]]
-
 
+
*[[Axin 3D structures|Axin 3D structures]]
-
<!--
+
__TOC__
-
The line below this paragraph, {{ABSTRACT_PUBMED_017529994}}, adds the Publication Abstract to the page
+
</StructureSection>
-
(as it appears on PubMed at http://www.pubmed.gov), where 017529994 is the PubMed ID number.
+
[[Category: Large Structures]]
-
-->
+
-
{{ABSTRACT_PUBMED_017529994}}
+
-
 
+
-
==About this Structure==
+
-
[[1wsp]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WSP OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:017529994</ref><references group="xtra"/>
+
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
-
[[Category: Hanamura, T.]]
+
[[Category: Hanamura T]]
-
[[Category: Higuchi, Y.]]
+
[[Category: Higuchi Y]]
-
[[Category: Kikuchi, A.]]
+
[[Category: Kikuchi A]]
-
[[Category: Shibata, N.]]
+
[[Category: Shibata N]]
-
[[Category: Ueda, Y.]]
+
[[Category: Ueda Y]]
-
[[Category: Yamamoto, H.]]
+
[[Category: Yamamoto H]]
-
[[Category: Yamamoto, R.]]
+
[[Category: Yamamoto R]]
-
[[Category: Signaling protein]]
+

Current revision

Crystal structure of axin dix domain

PDB ID 1wsp

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wsp"
Personal tools