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2b2a

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[[Image:2b2a.png|left|200px]]
 
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==Crystal Structure of the TEN domain of the Telomerase Reverse Transcriptase==
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<StructureSection load='2b2a' size='340' side='right'caption='[[2b2a]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2b2a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B2A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2a OCA], [https://pdbe.org/2b2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b2a RCSB], [https://www.ebi.ac.uk/pdbsum/2b2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b2a ProSAT]</span></td></tr>
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{{STRUCTURE_2b2a| PDB=2b2a | SCENE= }}
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</table>
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== Function ==
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===Crystal Structure of the TEN domain of the Telomerase Reverse Transcriptase===
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[https://www.uniprot.org/uniprot/TERT_TETTS TERT_TETTS] Catalytic component of telomerase, an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:10944124, PubMed:15696174, PubMed:17322903, PubMed:20713447, PubMed:16462747). TERT is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme (PubMed:10944124, PubMed:15696174, PubMed:17322903, PubMed:20713447, PubMed:16462747).<ref>PMID:10944124</ref> <ref>PMID:15696174</ref> <ref>PMID:16462747</ref> <ref>PMID:17322903</ref> <ref>PMID:20713447</ref>
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(as it appears on PubMed at http://www.pubmed.gov), where 16462747 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16462747}}
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==About this Structure==
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[[2b2a]] is a 3 chain structure of [[Reverse transcriptase]], [[Telomerase]] and [[Telomerase Reverse Transcriptase]] with sequence from [http://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2A OCA].
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==See Also==
==See Also==
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*[[Reverse transcriptase|Reverse transcriptase]]
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*[[Telomerase 3D structures|Telomerase 3D structures]]
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*[[Telomerase|Telomerase]]
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*[[Telomerase Reverse Transcriptase|Telomerase Reverse Transcriptase]]
*[[Telomerase Reverse Transcriptase|Telomerase Reverse Transcriptase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016462747</ref><references group="xtra"/>
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__TOC__
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[[Category: RNA-directed DNA polymerase]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Tetrahymena thermophila]]
[[Category: Tetrahymena thermophila]]
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[[Category: Cech, T R.]]
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[[Category: Cech TR]]
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[[Category: Jacobs, S A.]]
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[[Category: Jacobs SA]]
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[[Category: Podell, E R.]]
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[[Category: Podell ER]]
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[[Category: Reverse transcriptase]]
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[[Category: Rt]]
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[[Category: Telomerase]]
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[[Category: Tert]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of the TEN domain of the Telomerase Reverse Transcriptase

PDB ID 2b2a

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