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3cb8

From Proteopedia

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[[Image:3cb8.png|left|200px]]
 
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==4Fe-4S-Pyruvate formate-lyase activating enzyme in complex with AdoMet and a peptide substrate==
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The line below this paragraph, containing "STRUCTURE_3cb8", creates the "Structure Box" on the page.
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<StructureSection load='3cb8' size='340' side='right'caption='[[3cb8]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cb8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CB8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.77&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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{{STRUCTURE_3cb8| PDB=3cb8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cb8 OCA], [https://pdbe.org/3cb8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cb8 RCSB], [https://www.ebi.ac.uk/pdbsum/3cb8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cb8 ProSAT]</span></td></tr>
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</table>
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===4Fe-4S-Pyruvate formate-lyase activating enzyme in complex with AdoMet and a peptide substrate===
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== Function ==
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[https://www.uniprot.org/uniprot/PFLA_ECOLI PFLA_ECOLI] Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_18852451}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 18852451 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cb/3cb8_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18852451}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[3cb8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CB8 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cb8 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:018852451</ref><references group="xtra"/>
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Drennan, C L.]]
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[[Category: Large Structures]]
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[[Category: Vey, J L.]]
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[[Category: Drennan CL]]
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[[Category: Activase]]
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[[Category: Vey JL]]
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[[Category: Adomet radical]]
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[[Category: Carbohydrate metabolism]]
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[[Category: Glucose metabolism]]
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[[Category: Glycyl radical]]
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[[Category: Iron]]
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[[Category: Iron-sulfur]]
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[[Category: Metal-binding]]
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[[Category: Oxidoreductase]]
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[[Category: Partial tim barrel]]
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[[Category: S-adenosyl-l-methionine]]
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[[Category: Sam radical]]
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Current revision

4Fe-4S-Pyruvate formate-lyase activating enzyme in complex with AdoMet and a peptide substrate

PDB ID 3cb8

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