3u32

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[[Image:3u32.png|left|200px]]
 
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==ATP synthase c10 ring reacted with DCCD at pH 5.5==
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The line below this paragraph, containing "STRUCTURE_3u32", creates the "Structure Box" on the page.
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<StructureSection load='3u32' size='340' side='right'caption='[[3u32]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3u32]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U32 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCW:DICYCLOHEXYLUREA'>DCW</scene>, <scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene></td></tr>
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{{STRUCTURE_3u32| PDB=3u32 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u32 OCA], [https://pdbe.org/3u32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u32 RCSB], [https://www.ebi.ac.uk/pdbsum/3u32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u32 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ATP9_YEAST ATP9_YEAST] Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The proton pore of the F(1)F(o) ATP synthase consists of a ring of c subunits, which rotates, driven by downhill proton diffusion across the membrane. An essential carboxylate side chain in each subunit provides a proton-binding site. In all the structures of c-rings reported to date, these sites are in a closed, ion-locked state. Structures are here presented of the c(10) ring from Saccharomyces cerevisiae determined at pH 8.3, 6.1 and 5.5, at resolutions of 2.0 A, 2.5 A and 2.0 A, respectively. The overall structure of this mitochondrial c-ring is similar to known homologs, except that the essential carboxylate, Glu59, adopts an open extended conformation. Molecular dynamics simulations reveal that opening of the essential carboxylate is a consequence of the amphiphilic nature of the crystallization buffer. We propose that this new structure represents the functionally open form of the c subunit, which facilitates proton loading and release.
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===ATP synthase c10 ring reacted with DCCD at pH 5.5===
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Structure of the c(10) ring of the yeast mitochondrial ATP synthase in the open conformation.,Symersky J, Pagadala V, Osowski D, Krah A, Meier T, Faraldo-Gomez JD, Mueller DM Nat Struct Mol Biol. 2012 Apr 15;19(5):485-91. doi: 10.1038/nsmb.2284. PMID:22504883<ref>PMID:22504883</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3u32" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22504883}}, adds the Publication Abstract to the page
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*[[ATPase 3D structures|ATPase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22504883 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22504883}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3u32]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U32 OCA].
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==Reference==
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<ref group="xtra">PMID:022504883</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Faraldo-Gomez, J.]]
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[[Category: Faraldo-Gomez J]]
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[[Category: Krah, A.]]
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[[Category: Krah A]]
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[[Category: Meier, T.]]
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[[Category: Meier T]]
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[[Category: Mueller, D M.]]
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[[Category: Mueller DM]]
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[[Category: Osowski, D.]]
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[[Category: Osowski D]]
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[[Category: Pagadala, V.]]
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[[Category: Pagadala V]]
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[[Category: Symersky, J.]]
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[[Category: Symersky J]]
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[[Category: C10 ring]]
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[[Category: Dccd-reacted]]
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[[Category: F1fo atp synthase]]
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[[Category: Membrane protein]]
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[[Category: Proton pore]]
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Current revision

ATP synthase c10 ring reacted with DCCD at pH 5.5

PDB ID 3u32

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