2ltp
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of the SANT2 domain of the human nuclear receptor corepressor 2 (NCoR2), Northeast Structural Genomics Consortium (NESG) target ID HR4636E== | |
| + | <StructureSection load='2ltp' size='340' side='right'caption='[[2ltp]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2ltp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LTP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LTP FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ltp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ltp OCA], [https://pdbe.org/2ltp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ltp RCSB], [https://www.ebi.ac.uk/pdbsum/2ltp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ltp ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. | ||
| - | + | ==See Also== | |
| - | + | *[[Nuclear receptor corepressor|Nuclear receptor corepressor]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith C]] | ||
| + | [[Category: Bellanda M]] | ||
| + | [[Category: Garcia M]] | ||
| + | [[Category: Houliston S]] | ||
| + | [[Category: Lemak A]] | ||
| + | [[Category: Min J]] | ||
| + | [[Category: Montecchio M]] | ||
| + | [[Category: Montelione GT]] | ||
| + | [[Category: Xu C]] | ||
| + | [[Category: Yee A]] | ||
Current revision
Solution structure of the SANT2 domain of the human nuclear receptor corepressor 2 (NCoR2), Northeast Structural Genomics Consortium (NESG) target ID HR4636E
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Bellanda M | Garcia M | Houliston S | Lemak A | Min J | Montecchio M | Montelione GT | Xu C | Yee A
