2lty

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2lty" [edit=sysop:move=sysop])
Current revision (06:57, 1 May 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 2lty is ON HOLD
+
==NEDD4L WW2 domain in complex with a Smad7 derived peptide==
 +
<StructureSection load='2lty' size='340' side='right'caption='[[2lty]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2lty]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LTY FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lty OCA], [https://pdbe.org/2lty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lty RCSB], [https://www.ebi.ac.uk/pdbsum/2lty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lty ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NED4L_HUMAN NED4L_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2.<ref>PMID:12911626</ref> <ref>PMID:15217910</ref> <ref>PMID:15489223</ref> <ref>PMID:15040001</ref> <ref>PMID:15496141</ref> <ref>PMID:15576372</ref> <ref>PMID:19144635</ref>
-
Authors: Macias, M.J., Aragon, E., Goerner, N., Xi, Q., Lopes, T., Gao, S., Massague, J.
+
==See Also==
-
 
+
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
-
Description: NEDD4L WW2 domain in complex with a Smad7 derived peptide.
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Aragon E]]
 +
[[Category: Gao S]]
 +
[[Category: Goerner N]]
 +
[[Category: Lopes T]]
 +
[[Category: Macias MJ]]
 +
[[Category: Massague J]]
 +
[[Category: Xi Q]]

Current revision

NEDD4L WW2 domain in complex with a Smad7 derived peptide

PDB ID 2lty

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2lty"
Personal tools