2ltz
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2ltz is ON HOLD Authors: Macias, M.J., Aragon, E., Goerner, N., Xi, Q., Lopes, T., Gao, S., Massague, J. Description: Smurf2 WW3 domain in complex ...) |
|||
| (10 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Smurf2 WW3 domain in complex with a Smad7 derived peptide== | |
| + | <StructureSection load='2ltz' size='340' side='right'caption='[[2ltz]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2ltz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LTZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LTZ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ltz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ltz OCA], [https://pdbe.org/2ltz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ltz RCSB], [https://www.ebi.ac.uk/pdbsum/2ltz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ltz ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SMUF2_HUMAN SMUF2_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.<ref>PMID:11389444</ref> <ref>PMID:12717440</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Aragon E]] | ||
| + | [[Category: Gao S]] | ||
| + | [[Category: Goerner N]] | ||
| + | [[Category: Lopes T]] | ||
| + | [[Category: Macias MJ]] | ||
| + | [[Category: Massague J]] | ||
| + | [[Category: Xi Q]] | ||
Current revision
Smurf2 WW3 domain in complex with a Smad7 derived peptide
| |||||||||||
Categories: Homo sapiens | Large Structures | Aragon E | Gao S | Goerner N | Lopes T | Macias MJ | Massague J | Xi Q
