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4fc6

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'''Unreleased structure'''
 
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The entry 4fc6 is ON HOLD
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==Studies on DCR shed new light on peroxisomal beta-oxidation: Crystal structure of the ternary complex of pDCR==
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<StructureSection load='4fc6' size='340' side='right'caption='[[4fc6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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Authors: Hua, T., Wu, D., Wang, J., Shaw, N., Liu, Z.-J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fc6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FC6 FirstGlance]. <br>
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Description: Studies on DCR shed new light on peroxisomal beta-oxidation: Crystal structure of the ternary complex of pDCR
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HXC:HEXANOYL-COENZYME+A'>HXC</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fc6 OCA], [https://pdbe.org/4fc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fc6 RCSB], [https://www.ebi.ac.uk/pdbsum/4fc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fc6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DECR2_HUMAN DECR2_HUMAN] Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Hua T]]
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[[Category: Liu Z-J]]
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[[Category: Shaw N]]
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[[Category: Wang J]]
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[[Category: Wu D]]

Current revision

Studies on DCR shed new light on peroxisomal beta-oxidation: Crystal structure of the ternary complex of pDCR

PDB ID 4fc6

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