4dhx

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[[Image:4dhx.jpg|left|200px]]
 
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==ENY2:GANP complex==
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The line below this paragraph, containing "STRUCTURE_4dhx", creates the "Structure Box" on the page.
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<StructureSection load='4dhx' size='340' side='right'caption='[[4dhx]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4dhx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DHX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dhx OCA], [https://pdbe.org/4dhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dhx RCSB], [https://www.ebi.ac.uk/pdbsum/4dhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dhx ProSAT]</span></td></tr>
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{{STRUCTURE_4dhx| PDB=4dhx | SCENE= }}
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</table>
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== Function ==
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===ENY2:GANP complex===
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[https://www.uniprot.org/uniprot/GANP_HUMAN GANP_HUMAN] Isoform GANP: Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells (By similarity). Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.<ref>PMID:22307388</ref> Isoform MCM3AP: Acetyltransferase targeting MCM3. Inhibits initiation of DNA replication, but not elongation.<ref>PMID:22307388</ref>
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== References ==
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<references/>
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 22307388 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22307388}}
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==About this Structure==
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[[4dhx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DHX OCA].
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==Reference==
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<ref group="xtra">PMID:022307388</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Jani, D.]]
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[[Category: Large Structures]]
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[[Category: Stewart, M.]]
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[[Category: Jani D]]
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[[Category: Mrna export]]
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[[Category: Stewart M]]
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[[Category: Transport protein-dna binding protein complex]]
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Current revision

ENY2:GANP complex

PDB ID 4dhx

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