2lob

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[[Image:2lob.jpg|left|200px]]
 
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==PDZ Domain of CAL (Cystic Fibrosis Transmembrane Regulator-Associated Ligand)==
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The line below this paragraph, containing "STRUCTURE_2lob", creates the "Structure Box" on the page.
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<StructureSection load='2lob' size='340' side='right'caption='[[2lob]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lob]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LOB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lob OCA], [https://pdbe.org/2lob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lob RCSB], [https://www.ebi.ac.uk/pdbsum/2lob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lob ProSAT]</span></td></tr>
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{{STRUCTURE_2lob| PDB=2lob | SCENE= }}
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</table>
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== Disease ==
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===PDZ Domain of CAL (Cystic Fibrosis Transmembrane Regulator-Associated Ligand)===
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[https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_16331976}}
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==About this Structure==
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[[2lob]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LOB OCA].
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==Reference==
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<ref group="xtra">PMID:016331976</ref><references group="xtra"/>
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[[Category: Channel-conductance-controlling ATPase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fellows, A.]]
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[[Category: Large Structures]]
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[[Category: Madden, D R.]]
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[[Category: Fellows A]]
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[[Category: Mierke, D F.]]
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[[Category: Madden DR]]
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[[Category: Piserchio, A.]]
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[[Category: Mierke DF]]
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[[Category: Peptide binding protein]]
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[[Category: Piserchio A]]
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[[Category: Structural protein-hydrolase complex]]
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Current revision

PDZ Domain of CAL (Cystic Fibrosis Transmembrane Regulator-Associated Ligand)

PDB ID 2lob

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OCA

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