4emh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:29, 17 October 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4emh.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of SpLsm4==
-
The line below this paragraph, containing "STRUCTURE_4emh", creates the "Structure Box" on the page.
+
<StructureSection load='4emh' size='340' side='right'caption='[[4emh]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[4emh]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EMH FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
{{STRUCTURE_4emh| PDB=4emh | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4emh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4emh OCA], [https://pdbe.org/4emh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4emh RCSB], [https://www.ebi.ac.uk/pdbsum/4emh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4emh ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/LSM4_SCHPO LSM4_SCHPO] Binds specifically to the 3'-terminal U-tract of U6 snRNA.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Sm-like (Lsm) proteins are ubiquitous and function in many aspects of RNA metabolism, including pre-mRNA splicing, nuclear RNA processing, mRNA decay and miRNA biogenesis. Here three crystal structures including Lsm3, Lsm4 and Lsm5/6/7 sub-complex from S. pombe are reported. These structures show that all the five individual Lsm subunits share a conserved Sm fold, and Lsm3, Lsm4, and Lsm5/6/7 form a heptamer, a trimer and a hexamer within the crystal lattice, respectively. Analytical ultracentrifugation indicates that Lsm3 and Lsm5/6/7 sub-complex exist in solution as a heptamer and a hexamer, respectively while Lsm4 undergoes a dynamic equilibrium between monomer and trimer in solution. RNA binding assays show that Lsm2/3 and Lsm5/6/7 bind to oligo(U) whereas no RNA binding is observed for Lsm3 and Lsm4. Analysis of the inter-subunit interactions in Lsm5/6/7 reveals the organization order among Lsm5, Lsm6 and Lsm7.
-
===Crystal structure of SpLsm4===
+
Crystal Structures of Lsm3, Lsm4 and Lsm5/6/7 from Schizosaccharomyces pombe.,Wu D, Jiang S, Bowler MW, Song H PLoS One. 2012;7(5):e36768. Epub 2012 May 17. PMID:22615807<ref>PMID:22615807</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_22615807}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 4emh" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 22615807 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_22615807}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
[[4emh]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EMH OCA].
+
[[Category: Schizosaccharomyces pombe 972h-]]
-
 
+
[[Category: Jiang SM]]
-
==Reference==
+
[[Category: Song HW]]
-
<ref group="xtra">PMID:022615807</ref><references group="xtra"/>
+
[[Category: Wu DH]]
-
[[Category: Schizosaccharomyces pombe]]
+
-
[[Category: Jiang, S M.]]
+
-
[[Category: Song, H W.]]
+
-
[[Category: Wu, D H.]]
+
-
[[Category: Lsm protein]]
+
-
[[Category: Mrna decay]]
+
-
[[Category: Pre-mrna splicing]]
+
-
[[Category: Rna binding protein]]
+
-
[[Category: Sm fold]]
+

Current revision

Crystal structure of SpLsm4

PDB ID 4emh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4emh"
Personal tools