4a6k

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[[Image:4a6k.jpg|left|200px]]
 
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==Crystal structure of Slm1-PH domain in complex with D-myo-Inositol-4- phosphate==
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The line below this paragraph, containing "STRUCTURE_4a6k", creates the "Structure Box" on the page.
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<StructureSection load='4a6k' size='340' side='right'caption='[[4a6k]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4a6k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A6K FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I4D:D-MYO-INOSITOL-4-PHOSPHATE'>I4D</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_4a6k| PDB=4a6k | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a6k OCA], [https://pdbe.org/4a6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a6k RCSB], [https://www.ebi.ac.uk/pdbsum/4a6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a6k ProSAT]</span></td></tr>
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</table>
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===Crystal structure of Slm1-PH domain in complex with D-myo-Inositol-4- phosphate===
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== Function ==
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[https://www.uniprot.org/uniprot/SLM1_YEAST SLM1_YEAST] Together with SLM2, effector of the TORC2- and calcineurin-signaling pathways. Phosphorylated and activated by TORC2 under favorable growth conditions. Mediates actin polarization via inhibition of calcineurin-dependent transcription. Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin. Dephosphorylation inhibits its interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization. Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis.<ref>PMID:15372071</ref> <ref>PMID:15689497</ref> <ref>PMID:16959779</ref> <ref>PMID:16738335</ref>
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22574179 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_22574179}}
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==About this Structure==
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[[4a6k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A6K OCA].
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==Reference==
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<ref group="xtra">PMID:022574179</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Anand, K.]]
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[[Category: Anand K]]
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[[Category: Gavin, A C.]]
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[[Category: Gavin AC]]
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[[Category: Maeda, K.]]
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[[Category: Maeda K]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of Slm1-PH domain in complex with D-myo-Inositol-4- phosphate

PDB ID 4a6k

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