3uxg

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[[Image:3uxg.jpg|left|200px]]
 
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==Crystal structure of RFXANK==
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The line below this paragraph, containing "STRUCTURE_3uxg", creates the "Structure Box" on the page.
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<StructureSection load='3uxg' size='340' side='right'caption='[[3uxg]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3uxg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UXG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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{{STRUCTURE_3uxg| PDB=3uxg | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uxg OCA], [https://pdbe.org/3uxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uxg RCSB], [https://www.ebi.ac.uk/pdbsum/3uxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uxg ProSAT]</span></td></tr>
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</table>
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===Crystal structure of RFXANK===
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== Disease ==
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[https://www.uniprot.org/uniprot/RFXK_HUMAN RFXK_HUMAN] Immunodeficiency by defective expression of HLA class 2. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:9806546</ref> <ref>PMID:10072068</ref> <ref>PMID:10725724</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/RFXK_HUMAN RFXK_HUMAN] Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. Isoform RFX-B-delta5 is not involved in the positive regulation of MHC class II genes.
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The line below this paragraph, {{ABSTRACT_PUBMED_22649097}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 22649097 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_22649097}}
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</StructureSection>
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==About this Structure==
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[[3uxg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UXG OCA].
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==Reference==
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<ref group="xtra">PMID:022649097</ref><references group="xtra"/>
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[[Category: Histone deacetylase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bian, C.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Bian C]]
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[[Category: Chao, X.]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M.]]
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[[Category: Chao X]]
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[[Category: Li, Y.]]
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[[Category: Edwards AM]]
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[[Category: Min, J.]]
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[[Category: Li Y]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Min J]]
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[[Category: Tempel, W.]]
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[[Category: Tempel W]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Ankyrin repeat]]
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[[Category: Histone]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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[[Category: Transcription]]
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Current revision

Crystal structure of RFXANK

PDB ID 3uxg

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OCA

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