2yly

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[[Image:2yly.jpg|left|200px]]
 
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==Sulfonamides as selective Estrogen Receptor beta Agonists.==
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The line below this paragraph, containing "STRUCTURE_2yly", creates the "Structure Box" on the page.
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<StructureSection load='2yly' size='340' side='right'caption='[[2yly]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2yly]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YLY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SU4:N-CYCLOPROPYL-4-OXIDANYL-N-[(2R)-2-OXIDANYL-2-PHENYL-PROPYL]BENZENESULFONAMIDE'>SU4</scene></td></tr>
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{{STRUCTURE_2yly| PDB=2yly | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yly OCA], [https://pdbe.org/2yly PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yly RCSB], [https://www.ebi.ac.uk/pdbsum/2yly PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yly ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A series of p-hydroxybenzenesulphonamides ERbeta receptor agonists were discovered and several compounds identified had excellent selectivity over the related ERalpha receptor. One of these, compound 11, had an interesting binding conformation determined by X-ray and represents an excellent starting point in the quest for further selective ERbeta agonists.
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===Sulfonamides as selective Estrogen Receptor beta Agonists.===
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Sulfonamides as selective oestrogen receptor beta agonists.,Roberts LR, Armor D, Barker C, Bent A, Bess K, Brown A, Favor DA, Ellis D, Irving SL, MacKenny M, Phillips C, Pullen N, Stennett A, Strand L, Styles M Bioorg Med Chem Lett. 2011 Oct 1;21(19):5680-3. Epub 2011 Aug 16. PMID:21885279<ref>PMID:21885279</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2yly" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21885279}}, adds the Publication Abstract to the page
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*[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21885279 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21885279}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2yly]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLY OCA].
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==Reference==
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<ref group="xtra">PMID:021885279</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Armour, D.]]
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[[Category: Large Structures]]
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[[Category: Barker, C.]]
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[[Category: Armour D]]
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[[Category: Bazin, R.]]
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[[Category: Barker C]]
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[[Category: Bess, K.]]
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[[Category: Bazin R]]
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[[Category: Brown, A.]]
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[[Category: Bess K]]
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[[Category: Ellis, D.]]
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[[Category: Brown A]]
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[[Category: Favor, D.]]
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[[Category: Ellis D]]
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[[Category: Mackenny, M.]]
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[[Category: Favor D]]
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[[Category: Phillips, C.]]
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[[Category: MacKenny M]]
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[[Category: Pullen, N.]]
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[[Category: Phillips C]]
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[[Category: Roberts, L R.]]
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[[Category: Pullen N]]
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[[Category: Stennett, A.]]
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[[Category: Roberts LR]]
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[[Category: Strand, L.]]
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[[Category: Stennett A]]
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[[Category: Styles, M.]]
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[[Category: Strand L]]
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[[Category: Receptor]]
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[[Category: Styles M]]

Current revision

Sulfonamides as selective Estrogen Receptor beta Agonists.

PDB ID 2yly

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