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4dcf

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[[Image:4dcf.jpg|left|200px]]
 
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==Structure of MTX-II from Bothrops brazili==
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The line below this paragraph, containing "STRUCTURE_4dcf", creates the "Structure Box" on the page.
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<StructureSection load='4dcf' size='340' side='right'caption='[[4dcf]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4dcf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_brazili Bothrops brazili]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DCF FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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{{STRUCTURE_4dcf| PDB=4dcf | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dcf OCA], [https://pdbe.org/4dcf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dcf RCSB], [https://www.ebi.ac.uk/pdbsum/4dcf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dcf ProSAT]</span></td></tr>
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</table>
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===Structure of MTX-II from Bothrops brazili===
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== Function ==
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[https://www.uniprot.org/uniprot/PA2H1_BOTBZ PA2H1_BOTBZ] Snake venom phospholipase A2 homolog that lacks enzymatic activity. Is myotoxic and displays edema-inducing activities in mouse paw (PubMed:18602430). Also displays cytotoxic activity against some cell lines, and antimicrobial activities against E.coli, C.albicans and Leishmania (PubMed:18602430). A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e.g. fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (PubMed:24145104). This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (PubMed:24145104). The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (PubMed:24145104). Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (PubMed:24145104). This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i.e. calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (PubMed:24145104).<ref>PMID:18602430</ref> <ref>PMID:24145104</ref>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22584077}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22584077 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22584077}}
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==About this Structure==
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[[4dcf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_brazili Bothrops brazili]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DCF OCA].
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==Reference==
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<ref group="xtra">PMID:022584077</ref><references group="xtra"/>
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[[Category: Bothrops brazili]]
[[Category: Bothrops brazili]]
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[[Category: Arni, R K.]]
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[[Category: Large Structures]]
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[[Category: Betzel, C.]]
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[[Category: Arni RK]]
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[[Category: Murakami, M T.]]
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[[Category: Betzel C]]
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[[Category: Souza, T A.C B.]]
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[[Category: Murakami MT]]
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[[Category: Ullah, A.]]
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[[Category: Souza TACB]]
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[[Category: Hydrolase]]
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[[Category: Ullah A]]
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[[Category: Lys49 phospholipase]]
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[[Category: Phospholipase]]
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Current revision

Structure of MTX-II from Bothrops brazili

PDB ID 4dcf

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