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4dtg

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[[Image:4dtg.jpg|left|200px]]
 
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==Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model==
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The line below this paragraph, containing "STRUCTURE_4dtg", creates the "Structure Box" on the page.
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<StructureSection load='4dtg' size='340' side='right'caption='[[4dtg]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4dtg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DTG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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{{STRUCTURE_4dtg| PDB=4dtg | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dtg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dtg OCA], [https://pdbe.org/4dtg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dtg RCSB], [https://www.ebi.ac.uk/pdbsum/4dtg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dtg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TFPI1_HUMAN TFPI1_HUMAN] Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
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===Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model===
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==See Also==
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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*[[Tissue factor pathway inhibitor|Tissue factor pathway inhibitor]]
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The line below this paragraph, {{ABSTRACT_PUBMED_22563084}}, adds the Publication Abstract to the page
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*[[3D structures of human antibody|3D structures of human antibody]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22563084 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_22563084}}
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==About this Structure==
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[[4dtg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DTG OCA].
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==Reference==
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<ref group="xtra">PMID:022563084</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Breinholt, J.]]
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[[Category: Large Structures]]
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[[Category: Hilden, I.]]
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[[Category: Breinholt J]]
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[[Category: Krogh, B O.]]
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[[Category: Hilden I]]
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[[Category: Svensson, L A.]]
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[[Category: Krogh BO]]
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[[Category: Antibody]]
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[[Category: Svensson LA]]
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[[Category: Blood clotting inhibitor-immune system complex]]
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[[Category: Blood coagulation]]
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[[Category: Inhibitor]]
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Current revision

Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model

PDB ID 4dtg

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