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4dg6

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[[Image:4dg6.jpg|left|200px]]
 
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==Crystal structure of domains 1 and 2 of LRP6==
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The line below this paragraph, containing "STRUCTURE_4dg6", creates the "Structure Box" on the page.
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<StructureSection load='4dg6' size='340' side='right'caption='[[4dg6]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4dg6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DG6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DG6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dg6 OCA], [https://pdbe.org/4dg6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dg6 RCSB], [https://www.ebi.ac.uk/pdbsum/4dg6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dg6 ProSAT]</span></td></tr>
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{{STRUCTURE_4dg6| PDB=4dg6 | SCENE= }}
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</table>
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== Disease ==
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===Crystal structure of domains 1 and 2 of LRP6===
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[[https://www.uniprot.org/uniprot/LRP6_HUMAN LRP6_HUMAN]] Coronary artery disease - hyperlipidemia - hypertension - diabetes - osteoporosis. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[https://www.uniprot.org/uniprot/LRP6_HUMAN LRP6_HUMAN]] Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).<ref>PMID:11448771</ref> <ref>PMID:11357136</ref> <ref>PMID:15778503</ref> <ref>PMID:16341017</ref> <ref>PMID:16513652</ref> <ref>PMID:17400545</ref> <ref>PMID:17326769</ref> <ref>PMID:19107203</ref> <ref>PMID:19801552</ref> <ref>PMID:19293931</ref>
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==About this Structure==
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== References ==
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[[4dg6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DG6 OCA].
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ceska, T A.]]
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[[Category: Large Structures]]
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[[Category: Doyle, C.]]
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[[Category: Ceska TA]]
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[[Category: Slocombe, P.]]
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[[Category: Doyle C]]
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[[Category: 6-bladed beta propeller]]
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[[Category: Slocombe P]]
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[[Category: Egf]]
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[[Category: Mesd]]
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[[Category: Sclerostin receptor]]
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[[Category: Signaling protein]]
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[[Category: Wnt]]
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Current revision

Crystal structure of domains 1 and 2 of LRP6

PDB ID 4dg6

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OCA

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