4eps

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[[Image:4eps.jpg|left|200px]]
 
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==Crystal structure of a fimbrial protein (BACOVA_04982) from Bacteroides ovatus ATCC 8483 at 1.85 A resolution==
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The line below this paragraph, containing "STRUCTURE_4eps", creates the "Structure Box" on the page.
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<StructureSection load='4eps' size='340' side='right'caption='[[4eps]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4eps]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_ovatus_ATCC_8483 Bacteroides ovatus ATCC 8483]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EPS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_4eps| PDB=4eps | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eps OCA], [https://pdbe.org/4eps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eps RCSB], [https://www.ebi.ac.uk/pdbsum/4eps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eps ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FIM1C_BACO1 FIM1C_BACO1] Probably a component of the fimbrium tip. Fimbriae are filamentous appendages on the cell surface that mediate cell adhesion and biofilm formation.<ref>PMID:27062925</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pili are proteinaceous polymers of linked pilins that protrude from the cell surface of many bacteria and often mediate adherence and virulence. We investigated a set of 20 Bacteroidia pilins from the human microbiome whose structures and mechanism of assembly were unknown. Crystal structures and biochemical data revealed a diverse protein superfamily with a common Greek-key beta sandwich fold with two transthyretin-like repeats that polymerize into a pilus through a strand-exchange mechanism. The assembly mechanism of the central, structural pilins involves proteinase-assisted removal of their N-terminal beta strand, creating an extended hydrophobic groove that binds the C-terminal donor strands of the incoming pilin. Accessory pilins at the tip and base have unique structural features specific to their location, allowing initiation or termination of the assembly. The Bacteroidia pilus, therefore, has a biogenesis mechanism that is distinct from other known pili and likely represents a different type of bacterial pilus.
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===Crystal structure of a hypothetical protein (BACOVA_04982) from Bacteroides ovatus ATCC 8483 at 1.85 A resolution===
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A Distinct Type of Pilus from the Human Microbiome.,Xu Q, Shoji M, Shibata S, Naito M, Sato K, Elsliger MA, Grant JC, Axelrod HL, Chiu HJ, Farr CL, Jaroszewski L, Knuth MW, Deacon AM, Godzik A, Lesley SA, Curtis MA, Nakayama K, Wilson IA Cell. 2016 Apr 21;165(3):690-703. doi: 10.1016/j.cell.2016.03.016. Epub 2016 Apr , 7. PMID:27062925<ref>PMID:27062925</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[4eps]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_ovatus Bacteroides ovatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EPS OCA].
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<div class="pdbe-citations 4eps" style="background-color:#fffaf0;"></div>
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[[Category: Bacteroides ovatus]]
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== References ==
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[[Category: JCSG, Joint Center for Structural Genomics.]]
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<references/>
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[[Category: Jcsg]]
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__TOC__
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[[Category: Joint center for structural genomic]]
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</StructureSection>
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[[Category: Protein structure initiative]]
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[[Category: Bacteroides ovatus ATCC 8483]]
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[[Category: Psi-biology]]
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[[Category: Large Structures]]
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[[Category: Structural genomic]]
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[[Category: Unknown function]]
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Current revision

Crystal structure of a fimbrial protein (BACOVA_04982) from Bacteroides ovatus ATCC 8483 at 1.85 A resolution

PDB ID 4eps

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OCA

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