This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.




2cek

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:08, 17 October 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2cek.png|left|200px]]
 
-
<!--
+
==Conformational Flexibility in the Peripheral Site of Torpedo californica Acetylcholinesterase Revealed by the Complex Structure with a Bifunctional Inhibitor==
-
The line below this paragraph, containing "STRUCTURE_2cek", creates the "Structure Box" on the page.
+
<StructureSection load='2cek' size='340' side='right'caption='[[2cek]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2cek]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CEK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CEK FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=N8T:N-[8-(1,2,3,4-TETRAHYDROACRIDIN-9-YLTHIO)OCTYL]-1,2,3,4-TETRAHYDROACRIDIN-9-AMINE'>N8T</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-
{{STRUCTURE_2cek| PDB=2cek | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cek OCA], [https://pdbe.org/2cek PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cek RCSB], [https://www.ebi.ac.uk/pdbsum/2cek PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cek ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ACES_TETCF ACES_TETCF] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ce/2cek_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cek ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The X-ray crystallographic structure of Torpedo californica acetylcholinesterase (TcAChE) in complex with the bifunctional inhibitor NF595, a potentially new anti-Alzheimer drug, has been solved. For the first time in TcAChE, a major conformational change in the peripheral-site tryptophan residue is observed upon complexation. The observed conformational flexibility highlights the dynamic nature of protein structures and is of importance for structure-based drug design.
-
===CONFORMATIONAL FLEXIBILITY IN THE PERIPHERAL SITE OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE REVEALED BY THE COMPLEX STRUCTURE WITH A BIFUNCTIONAL INHIBITOR===
+
Conformational flexibility in the peripheral site of Torpedo californica acetylcholinesterase revealed by the complex structure with a bifunctional inhibitor.,Colletier JP, Sanson B, Nachon F, Gabellieri E, Fattorusso C, Campiani G, Weik M J Am Chem Soc. 2006 Apr 12;128(14):4526-7. PMID:16594661<ref>PMID:16594661</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_16594661}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 2cek" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 16594661 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_16594661}}
+
-
 
+
-
==About this Structure==
+
-
[[2cek]] is a 1 chain structure of [[Acetylcholinesterase]] with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CEK OCA].
+
==See Also==
==See Also==
-
*[[Acetylcholinesterase|Acetylcholinesterase]]
+
*[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]]
-
*[[Torpedo californica acetylecholinesterase with bifunctional inhibitor|Torpedo californica acetylecholinesterase with bifunctional inhibitor]]
+
== References ==
-
 
+
<references/>
-
==Reference==
+
__TOC__
-
<ref group="xtra">PMID:016594661</ref><references group="xtra"/>
+
</StructureSection>
-
[[Category: Acetylcholinesterase]]
+
[[Category: Large Structures]]
-
[[Category: Torpedo californica]]
+
[[Category: Tetronarce californica]]
-
[[Category: Campiani, G.]]
+
[[Category: Campiani G]]
-
[[Category: Colletier, J P.]]
+
[[Category: Colletier JP]]
-
[[Category: Fattorusso, C.]]
+
[[Category: Fattorusso C]]
-
[[Category: Gabellieri, E.]]
+
[[Category: Gabellieri E]]
-
[[Category: Nachon, F.]]
+
[[Category: Nachon F]]
-
[[Category: Sanson, B.]]
+
[[Category: Sanson B]]
-
[[Category: Weik, M.]]
+
[[Category: Weik M]]
-
[[Category: Alpha/beta hydrolase]]
+
-
[[Category: Alzheimer disease]]
+
-
[[Category: Conformational flexibility]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Gpi-anchor]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Lipoprotein]]
+
-
[[Category: Neurotransmitter cleavage]]
+
-
[[Category: Neurotransmitter degradation]]
+
-
[[Category: Serine esterase]]
+
-
[[Category: Synapse]]
+
-
[[Category: Synapse membrane]]
+

Current revision

Conformational Flexibility in the Peripheral Site of Torpedo californica Acetylcholinesterase Revealed by the Complex Structure with a Bifunctional Inhibitor

PDB ID 2cek

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2cek"
Personal tools