2a07

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:10, 14 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2a07.png|left|200px]]
 
-
<!--
+
==Crystal Structure of Foxp2 bound Specifically to DNA.==
-
The line below this paragraph, containing "STRUCTURE_2a07", creates the "Structure Box" on the page.
+
<StructureSection load='2a07' size='340' side='right'caption='[[2a07]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2a07]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A07 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
{{STRUCTURE_2a07| PDB=2a07 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a07 OCA], [https://pdbe.org/2a07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a07 RCSB], [https://www.ebi.ac.uk/pdbsum/2a07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a07 ProSAT]</span></td></tr>
-
 
+
</table>
-
===Crystal Structure of Foxp2 bound Specifically to DNA.===
+
== Disease ==
-
 
+
[https://www.uniprot.org/uniprot/FOXP2_HUMAN FOXP2_HUMAN] Defects in FOXP2 are the cause of speech-language disorder 1 (SPCH1) [MIM:[https://omim.org/entry/602081 602081]; also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Affected individuals have a severe impairment in the selection and sequencing of fine orofacial movements, which are necessary for articulation. They also show deficits in several facets of language processing (such as the ability to break up words into their constituent phonemes) and grammatical skills.<ref>PMID:11586359</ref> Note=A chromosomal aberration involving FOXP2 is a cause of severe speech and language impairment. Translocation t(5;7)(q22;q31.2).
-
 
+
== Function ==
-
<!--
+
[https://www.uniprot.org/uniprot/FOXP2_HUMAN FOXP2_HUMAN] Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Involved in neural mechanisms mediating the development of speech and language.
-
The line below this paragraph, {{ABSTRACT_PUBMED_16407075}}, adds the Publication Abstract to the page
+
== Evolutionary Conservation ==
-
(as it appears on PubMed at http://www.pubmed.gov), where 16407075 is the PubMed ID number.
+
[[Image:Consurf_key_small.gif|200px|right]]
-
-->
+
Check<jmol>
-
{{ABSTRACT_PUBMED_16407075}}
+
<jmolCheckbox>
-
 
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a0/2a07_consurf.spt"</scriptWhenChecked>
-
==About this Structure==
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
[[2a07]] is a 10 chain structure of [[Forkhead box protein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A07 OCA].
+
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a07 ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[FOXP2|FOXP2]]
+
*[[FOX 3D structures|FOX 3D structures]]
-
*[[Forkhead box protein|Forkhead box protein]]
+
== References ==
-
*[[Foxp2 bound specifically to DNA|Foxp2 bound specifically to DNA]]
+
<references/>
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:016407075</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Bates, D L.]]
+
[[Category: Large Structures]]
-
[[Category: Chen, L.]]
+
[[Category: Bates DL]]
-
[[Category: Han, A.]]
+
[[Category: Chen L]]
-
[[Category: Nowick, K.]]
+
[[Category: Han A]]
-
[[Category: Paabo, S.]]
+
[[Category: Nowick K]]
-
[[Category: Stroud, J C.]]
+
[[Category: Paabo S]]
-
[[Category: Tong, H.]]
+
[[Category: Stroud JC]]
-
[[Category: Wu, Y.]]
+
[[Category: Tong H]]
-
[[Category: Double-helix]]
+
[[Category: Wu Y]]
-
[[Category: Forkhead]]
+
-
[[Category: Homodimer]]
+
-
[[Category: Magnesium]]
+
-
[[Category: Monomer]]
+
-
[[Category: Swapping]]
+
-
[[Category: Transcription-dna complex]]
+
-
[[Category: Winged-helix]]
+

Current revision

Crystal Structure of Foxp2 bound Specifically to DNA.

PDB ID 2a07

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2a07"
Personal tools