3g3a

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[[Image:3g3a.png|left|200px]]
 
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==Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen==
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The line below this paragraph, containing "STRUCTURE_3g3a", creates the "Structure Box" on the page.
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<StructureSection load='3g3a' size='340' side='right'caption='[[3g3a]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3g3a]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G3A FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g3a OCA], [https://pdbe.org/3g3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g3a RCSB], [https://www.ebi.ac.uk/pdbsum/3g3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g3a ProSAT]</span></td></tr>
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{{STRUCTURE_3g3a| PDB=3g3a | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/D0VX18_PETMA D0VX18_PETMA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g3/3g3a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g3a ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Variable lymphocyte receptors (VLRs) are leucine-rich repeat proteins that mediate adaptive immunity in jawless vertebrates. VLRs are fundamentally different from the antibodies of jawed vertebrates, which consist of immunoglobulin (Ig) domains. We determined the structure of an anti-hen egg white lysozyme (HEL) VLR, isolated by yeast display, bound to HEL. The VLR, whose affinity resembles that of IgM antibodies, uses nearly all its concave surface to bind the protein, in addition to a loop that penetrates into the enzyme active site. The VLR-HEL structure combined with sequence analysis revealed an almost perfect match between ligand-contacting positions and positions with highest sequence diversity. Thus, it is likely that we have defined the generalized antigen-binding site of VLRs. We further demonstrated that VLRs can be affinity-matured by 13-fold to affinities as high as those of IgG antibodies, making VLRs potential alternatives to antibodies for biotechnology applications.
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===Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen===
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Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen.,Velikovsky CA, Deng L, Tasumi S, Iyer LM, Kerzic MC, Aravind L, Pancer Z, Mariuzza RA Nat Struct Mol Biol. 2009 Jul;16(7):725-30. Epub 2009 Jun 21. PMID:19543291<ref>PMID:19543291</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3g3a" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19543291 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19543291}}
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==About this Structure==
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[[3g3a]] is a 8 chain structure of [[Hen Egg-White (HEW) Lysozyme]], [[Lamprey Variable Lymphocyte Receptor]], [[Variable Lymphocyte Receptors]] and [[Variable lymphocyte receptor]] with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G3A OCA].
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==See Also==
==See Also==
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*[[Hen Egg-White (HEW) Lysozyme|Hen Egg-White (HEW) Lysozyme]]
 
*[[Lamprey Variable Lymphocyte Receptor|Lamprey Variable Lymphocyte Receptor]]
*[[Lamprey Variable Lymphocyte Receptor|Lamprey Variable Lymphocyte Receptor]]
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*[[Variable Lymphocyte Receptors|Variable Lymphocyte Receptors]]
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
*[[Variable lymphocyte receptor|Variable lymphocyte receptor]]
*[[Variable lymphocyte receptor|Variable lymphocyte receptor]]
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*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:019543291</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Lysozyme]]
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[[Category: Large Structures]]
[[Category: Petromyzon marinus]]
[[Category: Petromyzon marinus]]
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[[Category: Deng, L.]]
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[[Category: Deng L]]
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[[Category: Mariuzza, R A.]]
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[[Category: Mariuzza RA]]
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[[Category: Velikovsky, C A.]]
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[[Category: Velikovsky CA]]
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[[Category: Allergen]]
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[[Category: Antibody]]
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[[Category: Antimicrobial]]
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[[Category: Bacteriolytic enzyme]]
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[[Category: Glycosidase]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-immune system complex]]
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[[Category: Vlr]]
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Current revision

Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen

PDB ID 3g3a

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