4aii

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[[Image:4aii.png|left|200px]]
 
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==Crystal structure of the rat REM2 GTPase - G domain bound to GDP==
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The line below this paragraph, containing "STRUCTURE_4aii", creates the "Structure Box" on the page.
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<StructureSection load='4aii' size='340' side='right'caption='[[4aii]], [[Resolution|resolution]] 2.66&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4aii]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AII OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AII FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.66&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_4aii| PDB=4aii | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aii OCA], [https://pdbe.org/4aii PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aii RCSB], [https://www.ebi.ac.uk/pdbsum/4aii PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aii ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/REM2_RAT REM2_RAT] Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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RGK proteins are atypical small GTP-binding proteins that are involved in the regulation of voltage-dependent calcium channels and actin cytoskeleton remodelling. The structure of the Rem2 G domain bound to GDP is reported here in a monoclinic crystal form at 2.66 A resolution. It is very similar to the structure determined previously from an orthorhombic crystal form. However, differences in the crystal-packing environment revealed that the switch I and switch II regions are flexible and not ordered as previously reported. Comparison of the available RGK protein structures along with those of other small GTP-binding proteins highlights two structural features characteristic of this atypical family and suggests that the conserved tryptophan residue in the DXWEX motif may be a structural determinant of the nucleotide-binding affinity.
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===Crystal structure of the rat REM2 GTPase - G domain bound to GDP===
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Structure of the GDP-bound G domain of the RGK protein Rem2.,Reymond P, Coquard A, Chenon M, Zeghouf M, El Marjou A, Thompson A, Menetrey J Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jun 1;68(Pt 6):626-31., Epub 2012 May 22. PMID:22684057<ref>PMID:22684057</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4aii" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22684057}}, adds the Publication Abstract to the page
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22684057 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22684057}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[4aii]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AII OCA].
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==Reference==
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<ref group="xtra">PMID:022684057</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Chenon, M.]]
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[[Category: Chenon M]]
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[[Category: Coquard, A.]]
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[[Category: Coquard A]]
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[[Category: Marjou, A El.]]
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[[Category: El Marjou A]]
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[[Category: Menetrey, J.]]
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[[Category: Menetrey J]]
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[[Category: Reymond, P.]]
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[[Category: Reymond P]]
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[[Category: Thompson, A.]]
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[[Category: Thompson A]]
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[[Category: Zeghouf, M.]]
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[[Category: Zeghouf M]]
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[[Category: Gtp-binding protein]]
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[[Category: Rgk protein]]
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Current revision

Crystal structure of the rat REM2 GTPase - G domain bound to GDP

PDB ID 4aii

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