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4dkq

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[[Image:4dkq.png|left|200px]]
 
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==Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with DMJ-I-228==
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The line below this paragraph, containing "STRUCTURE_4dkq", creates the "Structure Box" on the page.
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<StructureSection load='4dkq' size='340' side='right'caption='[[4dkq]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4dkq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(BRU_ISOLATE) Human immunodeficiency virus type 1 (BRU ISOLATE)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DKQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.888&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0LK:N-[(1S,2S)-2-CARBAMIMIDAMIDO-2,3-DIHYDRO-1H-INDEN-1-YL]-N-(4-CHLORO-3-FLUOROPHENYL)ETHANEDIAMIDE'>0LK</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_4dkq| PDB=4dkq | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dkq OCA], [https://pdbe.org/4dkq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dkq RCSB], [https://www.ebi.ac.uk/pdbsum/4dkq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dkq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q0ED31_9HIV1 Q0ED31_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).
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===Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with DMJ-I-228===
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==See Also==
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*[[Gp120 3D structures|Gp120 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_22497421}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22497421 is the PubMed ID number.
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[[Category: Courter JR]]
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[[Category: Freire E]]
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{{ABSTRACT_PUBMED_22497421}}
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[[Category: Jones DM]]
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[[Category: Kobayashi T]]
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==About this Structure==
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[[Category: Kwon YD]]
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[[4dkq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKQ OCA].
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[[Category: Kwong PD]]
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[[Category: LaLonde JM]]
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==Reference==
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[[Category: Madani N]]
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<ref group="xtra">PMID:022497421</ref><references group="xtra"/>
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[[Category: Mascola J]]
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[[Category: Human immunodeficiency virus 1]]
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[[Category: Princiotto AM]]
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[[Category: Courter, J R.]]
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[[Category: Schon A]]
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[[Category: Freire, E.]]
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[[Category: Smith III AB]]
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[[Category: III, A B.Smith.]]
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[[Category: Sodroski J]]
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[[Category: Jones, D M.]]
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[[Category: Soeta T]]
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[[Category: Kobayashi, T.]]
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[[Category: Sun AW]]
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[[Category: Kwon, Y D.]]
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[[Category: Wu X]]
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[[Category: Kwong, P D.]]
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[[Category: LaLonde, J M.]]
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[[Category: Madani, N.]]
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[[Category: Mascola, J.]]
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[[Category: Princiotto, A M.]]
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[[Category: Schon, A.]]
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[[Category: Sodroski, J.]]
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[[Category: Soeta, T.]]
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[[Category: Sun, A W.]]
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[[Category: Wu, X.]]
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[[Category: Cd4 mimic]]
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[[Category: Clade a/e]]
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[[Category: Dmj-i-228]]
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[[Category: Hiv-1 gp120]]
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[[Category: Viral protein-inhibitor complex]]
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Current revision

Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with DMJ-I-228

PDB ID 4dkq

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