2i1b

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[[Image:2i1b.jpg|left|200px]]<br /><applet load="2i1b" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2i1b, resolution 2.0&Aring;" />
 
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'''CRYSTALLOGRAPHIC REFINEMENT OF INTERLEUKIN-1 BETA AT 2.0 ANGSTROMS RESOLUTION'''<br />
 
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==Overview==
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==CRYSTALLOGRAPHIC REFINEMENT OF INTERLEUKIN-1 BETA AT 2.0 ANGSTROMS RESOLUTION==
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The structure of human recombinant interleukin 1 beta (IL-1 beta) has been, refined by a restrained least-squares method to a crystallographic R, factor of 17.2% to 2.0 A resolution. One-hundred sixty-eight solvent, molecules have been located, and isotropic temperature factors for each, atom have been refined. The overall structure is composed of 12, beta-strands that can best be described as forming the four triangular, faces of a tetrahedron with hydrogen bonding resembling normal, antiparallel beta-sheets only at the vertices. The interior of this, tetrahedron is filled by hydrophobic side chains. Analysis of sequence, alignments with IL-1 beta from other mammalian species shows the interior, to be very well conserved with the exterior residues markedly less so., There does not appear to be a clustering of invariant amino acid side, chains on the surface of the molecule, suggesting an area of interaction, with the IL-1 receptor. Comparison of the IL-1 beta structure with IL-1, alpha sequences indicates that IL-1 alpha probably has a similar overall, folding as IL-1 beta but binds to the receptor in a different fashion. The, three-dimensional structure of the IL-1 beta is analyzed in light of what, has been suggested by previously published work on mutants and fragments, of the molecule.
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<StructureSection load='2i1b' size='340' side='right'caption='[[2i1b]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2i1b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I1B FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1b OCA], [https://pdbe.org/2i1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i1b RCSB], [https://www.ebi.ac.uk/pdbsum/2i1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1b ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/2i1b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i1b ConSurf].
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<div style="clear:both"></div>
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==Disease==
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==See Also==
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Known disease associated with this structure: Gastric cancer risk after H. pylori infection OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147720 147720]]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2I1B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1B OCA].
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__TOC__
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</StructureSection>
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==Reference==
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Crystallographic refinement of interleukin 1 beta at 2.0 A resolution., Priestle JP, Schar HP, Grutter MG, Proc Natl Acad Sci U S A. 1989 Dec;86(24):9667-71. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2602367 2602367]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Gruetter, M.G.]]
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[[Category: Gruetter MG]]
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[[Category: Priestle, J.P.]]
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[[Category: Priestle JP]]
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[[Category: Schaer, H.P.]]
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[[Category: Schaer H-P]]
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[[Category: cytokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:34:33 2008''
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CRYSTALLOGRAPHIC REFINEMENT OF INTERLEUKIN-1 BETA AT 2.0 ANGSTROMS RESOLUTION

PDB ID 2i1b

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