4fl9
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4fl9 is ON HOLD Authors: Grimm, C. Description: Crystal Structure of bovine hsc70(aa1-554)E213A/D214A at 1.9A Resolution) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of bovine hsc70(aa1-554)E213A/D214A at 1.9A Resolution== | |
| + | <StructureSection load='4fl9' size='340' side='right'caption='[[4fl9]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4fl9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FL9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.901Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=TMO:TRIMETHYLAMINE+OXIDE'>TMO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fl9 OCA], [https://pdbe.org/4fl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fl9 RCSB], [https://www.ebi.ac.uk/pdbsum/4fl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fl9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HSP7C_BOVIN HSP7C_BOVIN] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Bos taurus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Grimm C]] | ||
Current revision
Crystal Structure of bovine hsc70(aa1-554)E213A/D214A at 1.9A Resolution
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