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2i7n

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[[Image:2i7n.jpg|left|200px]]<br /><applet load="2i7n" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2i7n, resolution 1.90&Aring;" />
 
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'''Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA'''<br />
 
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==Disease==
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==Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA==
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Known diseases associated with this structure: HARP syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606157 606157]], Neurodegeneration, pantothenate kinase-associated OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606157 606157]]
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<StructureSection load='2i7n' size='340' side='right'caption='[[2i7n]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2i7n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I7N FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7n OCA], [https://pdbe.org/2i7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i7n RCSB], [https://www.ebi.ac.uk/pdbsum/2i7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i7n ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PANK1_HUMAN PANK1_HUMAN] Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i7/2i7n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i7n ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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2I7N is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ACO:'>ACO</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA].
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*[[Pantothenate kinase 3D structures|Pantothenate kinase 3D structures]]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Pantothenate kinase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Allali-Hassani A]]
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[[Category: Allali-Hassani, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C.H.]]
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[[Category: Bochkarev A]]
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[[Category: Bochkarev, A.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A.M.]]
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[[Category: Hong BS]]
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[[Category: Hong, B.]]
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[[Category: Loppnau P]]
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[[Category: Loppnau, P.]]
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[[Category: Park HW]]
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[[Category: Park, H.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Tempel W]]
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[[Category: Tempel, W.]]
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[[Category: Wang L]]
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[[Category: Wang, L.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: ACO]]
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[[Category: pank]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:35:06 2008''
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Current revision

Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA

PDB ID 2i7n

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