2ltp

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[[Image:2ltp.jpg|left|200px]]
 
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{{STRUCTURE_2ltp| PDB=2ltp | SCENE= }}
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==Solution structure of the SANT2 domain of the human nuclear receptor corepressor 2 (NCoR2), Northeast Structural Genomics Consortium (NESG) target ID HR4636E==
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<StructureSection load='2ltp' size='340' side='right'caption='[[2ltp]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ltp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LTP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LTP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ltp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ltp OCA], [https://pdbe.org/2ltp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ltp RCSB], [https://www.ebi.ac.uk/pdbsum/2ltp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ltp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
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===Solution structure of the SANT2 domain of the human nuclear receptor corepressor 2 (NCoR2), Northeast Structural Genomics Consortium (NESG) target ID HR4636E===
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==See Also==
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*[[Nuclear receptor corepressor|Nuclear receptor corepressor]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[2ltp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LTP OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Bellanda, M.]]
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[[Category: Arrowsmith C]]
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[[Category: Garcia, M.]]
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[[Category: Bellanda M]]
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[[Category: Houliston, S.]]
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[[Category: Garcia M]]
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[[Category: Lemak, A.]]
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[[Category: Houliston S]]
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[[Category: Min, J.]]
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[[Category: Lemak A]]
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[[Category: Montecchio, M.]]
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[[Category: Min J]]
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[[Category: Montelione, G T.]]
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[[Category: Montecchio M]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Montelione GT]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Xu C]]
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[[Category: Xu, C.]]
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[[Category: Yee A]]
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[[Category: Yee, A.]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Sgc]]
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[[Category: Smrt]]
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[[Category: Structural genomics consortium]]
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[[Category: Trac]]
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[[Category: Transcription regulator]]
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Current revision

Solution structure of the SANT2 domain of the human nuclear receptor corepressor 2 (NCoR2), Northeast Structural Genomics Consortium (NESG) target ID HR4636E

PDB ID 2ltp

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OCA

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