3v8p
From Proteopedia
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| - | [[Image:3v8p.png|left|200px]] | ||
| - | + | ==Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a new di-adenosine inhibitor formed in situ== | |
| + | <StructureSection load='3v8p' size='340' side='right'caption='[[3v8p]], [[Resolution|resolution]] 2.29Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3v8p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V8P FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2901Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=ZNB:2-[6-azanyl-9-[(2R,3R,4S,5R)-5-[[(azanylidene-$l^{4}-azanylidene)amino]methyl]-3,4-bis(oxidanyl)oxolan-2-yl]purin-8-yl]sulfanyl-N-[[(2R,3S,4R,5R)-5-(6-azanyl-8-bromanyl-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]ethanamide'>ZNB</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v8p OCA], [https://pdbe.org/3v8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v8p RCSB], [https://www.ebi.ac.uk/pdbsum/3v8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v8p ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NADK1_LISMO NADK1_LISMO] Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.[HAMAP-Rule:MF_00361]<ref>PMID:17686780</ref> <ref>PMID:22608967</ref> | ||
| - | == | + | ==See Also== |
| - | + | *[[NAD kinase|NAD kinase]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | [[ | + | </StructureSection> |
| - | + | [[Category: Large Structures]] | |
| - | == | + | |
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[[Category: Listeria monocytogenes]] | [[Category: Listeria monocytogenes]] | ||
| - | [[Category: Assairi | + | [[Category: Assairi L]] |
| - | [[Category: Dugu | + | [[Category: Dugu L]] |
| - | [[Category: Dussurget | + | [[Category: Dussurget O]] |
| - | [[Category: Gelin | + | [[Category: Gelin M]] |
| - | [[Category: Huteau | + | [[Category: Huteau V]] |
| - | [[Category: Labesse | + | [[Category: Labesse G]] |
| - | [[Category: Morellato | + | [[Category: Morellato L]] |
| - | [[Category: Pochet | + | [[Category: Pochet S]] |
| - | [[Category: Poncet-Montange | + | [[Category: Poncet-Montange G]] |
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Current revision
Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a new di-adenosine inhibitor formed in situ
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