3tls
From Proteopedia
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| - | [[Image:3tls.png|left|200px]] | ||
| - | + | ==The GLIC pentameric Ligand-Gated Ion Channel E19'P mutant in a locally-closed conformation (LC2 subtype)== | |
| - | + | <StructureSection load='3tls' size='340' side='right'caption='[[3tls]], [[Resolution|resolution]] 3.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3tls]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TLS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tls OCA], [https://pdbe.org/3tls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tls RCSB], [https://www.ebi.ac.uk/pdbsum/3tls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tls ProSAT]</span></td></tr> |
| - | [[3tls]] is a 5 chain structure | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Phosphoinositide 3- | + | *[[Ion channels 3D structures|Ion channels 3D structures]] |
| - | + | *[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]] | |
| - | == | + | == References == |
| - | < | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Gloeobacter violaceus]] | [[Category: Gloeobacter violaceus]] | ||
| - | [[Category: Corringer | + | [[Category: Large Structures]] |
| - | [[Category: Delarue | + | [[Category: Corringer PJ]] |
| - | [[Category: Nury | + | [[Category: Delarue M]] |
| - | [[Category: Sauguet | + | [[Category: Nury H]] |
| - | + | [[Category: Sauguet L]] | |
| - | + | ||
| - | + | ||
Current revision
The GLIC pentameric Ligand-Gated Ion Channel E19'P mutant in a locally-closed conformation (LC2 subtype)
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