2qtj

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<applet load="2qtj" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2qtj" />
 
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'''Solution structure of human dimeric immunoglobulin A'''<br />
 
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==Overview==
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==Solution structure of human dimeric immunoglobulin A==
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IgA is unique in being able to form a diverse range of polymeric, structures. Increases in the levels of dimeric IgA1 (dIgA1) in serum have, been implicated in diseases such as IgA nephropathy. We have determined, the solution structure for dIgA1 by synchrotron x-ray and neutron, scattering and analytical ultracentrifugation. The Guinier radius of, gyration (R(G)) of 7.60-8.65 nm indicated that the two monomers within, dIgA1 are arranged in an extended conformation. The distance distribution, curve P(r) gave an overall length (L) of 22-26 nm. These results were, confirmed by the sedimentation coefficient and frictional ratio of dIgA1., Constrained scattering modeling starting from the IgA1 monomer solution, structure revealed a near-planar dimer structure for dIgA1. The two Fc, regions form a slightly bent arrangement in which they form end-to-end, contacts, and the J chain was located at this interface. This structure, was refined by optimizing the position of the four Fab regions. From this, the best-fit solution structures show that the four Fab Ag-binding sites, are independent of one another, and the two Fc regions are accessible to, receptor binding. This arrangement allows dIgA1 to initiate specific, immune responses by binding to FcalphaRI receptors, while still retaining, Ag-binding ability, and to be selectively transported to mucosal surfaces, by binding to the polymeric Ig receptor to form secretory IgA. A mechanism, for the involvement of dIgA1 oligomers in the pathology of IgA nephropathy, is discussed in the light of this near-planar structure.
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<StructureSection load='2qtj' size='340' side='right'caption='[[2qtj]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2qtj]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QTJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QTJ FirstGlance]. <br>
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2QTJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QTJ OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qtj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qtj OCA], [https://pdbe.org/2qtj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qtj RCSB], [https://www.ebi.ac.uk/pdbsum/2qtj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qtj ProSAT]</span></td></tr>
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==Reference==
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</table>
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Implications of the near-planar solution structure of human myeloma dimeric IgA1 for mucosal immunity and IgA nephropathy., Bonner A, Furtado PB, Almogren A, Kerr MA, Perkins SJ, J Immunol. 2008 Jan 15;180(2):1008-18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18178841 18178841]
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== Function ==
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[https://www.uniprot.org/uniprot/Q6MZW0_HUMAN Q6MZW0_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qt/2qtj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qtj ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Almogren, A.]]
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[[Category: Almogren A]]
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[[Category: Bonner, A.]]
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[[Category: Bonner A]]
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[[Category: Furtado, P.B.]]
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[[Category: Furtado PB]]
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[[Category: Kerr, M.A.]]
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[[Category: Kerr MA]]
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[[Category: Perkins, S.J.]]
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[[Category: Perkins SJ]]
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[[Category: antibody]]
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[[Category: chromophore]]
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[[Category: direct protein sequencing]]
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[[Category: glycoprotein]]
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[[Category: immune system]]
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[[Category: immunoglobulin a1]]
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[[Category: immunoglobulin c region]]
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[[Category: immunoglobulin domain]]
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[[Category: immunology]]
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[[Category: polymorphism]]
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[[Category: x-ray and neutron solution scattering]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:42:01 2008''
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Current revision

Solution structure of human dimeric immunoglobulin A

PDB ID 2qtj

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