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4evd

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[[Image:4evd.jpg|left|200px]]
 
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{{STRUCTURE_4evd| PDB=4evd | SCENE= }}
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==Crystal Structure HP-NAP from strain YS29 cadmium loaded (Cocrystallization 50mM)==
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<StructureSection load='4evd' size='340' side='right'caption='[[4evd]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4evd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EVD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4evd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4evd OCA], [https://pdbe.org/4evd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4evd RCSB], [https://www.ebi.ac.uk/pdbsum/4evd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4evd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/G1UIZ2_HELPX G1UIZ2_HELPX]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Helicobacter pylori neutrophil-activating protein (HP-NAP) is a Dps-like iron storage protein forming a dodecameric shell, and promotes adhesion of neutrophils to endothelial cells. The crystal structure of HP-NAP in a Zn(2+)- or Cd(2+)-bound form reveals the binding of two zinc or two cadmium ions and their bridged water molecule at the ferroxidase center (FOC). The two zinc ions are coordinated in a tetrahedral manner to the conserved residues among HP-NAP and Dps proteins. The two cadmium ions are coordinated in a trigonal-bipyramidal and distorted octahedral manner. In both structures, the second ion is more weakly coordinated than the first. Another zinc ion is found inside of the negatively-charged threefold-related pore, which is suitable for metal ions to pass through.
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===Crystal Structure HP-NAP from strain YS29 cadmium loaded (Cocrystallization 50mM)===
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Crystal structure of Helicobacter pylori neutrophil-activating protein with a di-nuclear ferroxidase center in a zinc or cadmium-bound form.,Yokoyama H, Tsuruta O, Akao N, Fujii S Biochem Biophys Res Commun. 2012 Jun 15;422(4):745-50. Epub 2012 May 19. PMID:22618234<ref>PMID:22618234</ref>
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{{ABSTRACT_PUBMED_22618234}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 4evd" style="background-color:#fffaf0;"></div>
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[[4evd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EVD OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:022618234</ref><ref group="xtra">PMID:022297984</ref><references group="xtra"/>
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</StructureSection>
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
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[[Category: Akao, N.]]
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[[Category: Large Structures]]
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[[Category: Fujii, S.]]
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[[Category: Akao N]]
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[[Category: Tsuruta, O.]]
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[[Category: Fujii S]]
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[[Category: Yokoyama, H.]]
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[[Category: Tsuruta O]]
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[[Category: Dodecamer]]
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[[Category: Yokoyama H]]
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[[Category: Four-helix bundle]]
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[[Category: Metal transport]]
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Current revision

Crystal Structure HP-NAP from strain YS29 cadmium loaded (Cocrystallization 50mM)

PDB ID 4evd

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