This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4evb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:49, 8 November 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4evb.jpg|left|200px]]
 
-
{{STRUCTURE_4evb| PDB=4evb | SCENE= }}
+
==Crystal Structure HP-NAP from strain YS39 zinc soaked (20mM)==
 +
<StructureSection load='4evb' size='340' side='right'caption='[[4evb]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4evb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EVB FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4evb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4evb OCA], [https://pdbe.org/4evb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4evb RCSB], [https://www.ebi.ac.uk/pdbsum/4evb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4evb ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/G1UIZ3_HELPX G1UIZ3_HELPX]
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Helicobacter pylori neutrophil-activating protein (HP-NAP) is a Dps-like iron storage protein forming a dodecameric shell, and promotes adhesion of neutrophils to endothelial cells. The crystal structure of HP-NAP in a Zn(2+)- or Cd(2+)-bound form reveals the binding of two zinc or two cadmium ions and their bridged water molecule at the ferroxidase center (FOC). The two zinc ions are coordinated in a tetrahedral manner to the conserved residues among HP-NAP and Dps proteins. The two cadmium ions are coordinated in a trigonal-bipyramidal and distorted octahedral manner. In both structures, the second ion is more weakly coordinated than the first. Another zinc ion is found inside of the negatively-charged threefold-related pore, which is suitable for metal ions to pass through.
-
===Crystal Structure HP-NAP from strain YS39 zinc soaked (20mM)===
+
Crystal structure of Helicobacter pylori neutrophil-activating protein with a di-nuclear ferroxidase center in a zinc or cadmium-bound form.,Yokoyama H, Tsuruta O, Akao N, Fujii S Biochem Biophys Res Commun. 2012 Jun 15;422(4):745-50. Epub 2012 May 19. PMID:22618234<ref>PMID:22618234</ref>
-
{{ABSTRACT_PUBMED_22618234}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 4evb" style="background-color:#fffaf0;"></div>
-
[[4evb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EVB OCA].
+
== References ==
-
 
+
<references/>
-
==Reference==
+
__TOC__
-
<ref group="xtra">PMID:022618234</ref><ref group="xtra">PMID:022297984</ref><references group="xtra"/>
+
</StructureSection>
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
-
[[Category: Akao, N.]]
+
[[Category: Large Structures]]
-
[[Category: Fujii, S.]]
+
[[Category: Akao N]]
-
[[Category: Tsuruta, O.]]
+
[[Category: Fujii S]]
-
[[Category: Yokoyama, H.]]
+
[[Category: Tsuruta O]]
-
[[Category: Dodecamer]]
+
[[Category: Yokoyama H]]
-
[[Category: Four-helix bundle]]
+
-
[[Category: Metal transport]]
+

Current revision

Crystal Structure HP-NAP from strain YS39 zinc soaked (20mM)

PDB ID 4evb

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4evb"
Personal tools