2lr8

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[[Image:2lr8.jpg|left|200px]]
 
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{{STRUCTURE_2lr8| PDB=2lr8 | SCENE= }}
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==Solution NMR Structure of CASP8-associated protein 2 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8150A==
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<StructureSection load='2lr8' size='340' side='right'caption='[[2lr8]]' scene=''>
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===Solution NMR Structure of CASP8-associated protein 2 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8150A===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2lr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LR8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lr8 OCA], [https://pdbe.org/2lr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lr8 RCSB], [https://www.ebi.ac.uk/pdbsum/2lr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lr8 ProSAT]</span></td></tr>
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[[2lr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LR8 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/C8AP2_HUMAN C8AP2_HUMAN] Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.<ref>PMID:12477726</ref> <ref>PMID:15698540</ref> <ref>PMID:17003125</ref> <ref>PMID:17245429</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Acton, T B.]]
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[[Category: Large Structures]]
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[[Category: Eletsky, A.]]
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[[Category: Acton TB]]
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[[Category: Everett, J K.]]
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[[Category: Eletsky A]]
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[[Category: Janjua, H.]]
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[[Category: Everett JK]]
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[[Category: Kohan, E.]]
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[[Category: Janjua H]]
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[[Category: Lee, D.]]
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[[Category: Kohan E]]
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[[Category: Montelione, G T.]]
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[[Category: Lee D]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Montelione GT]]
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[[Category: Pulavarti, S.]]
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[[Category: Pulavarti S]]
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[[Category: Sathyamoorthy, B.]]
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[[Category: Sathyamoorthy B]]
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[[Category: Sukumaran, D K.]]
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[[Category: Sukumaran DK]]
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[[Category: Szyperski, T.]]
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[[Category: Szyperski T]]
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[[Category: Xiao, R.]]
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[[Category: Xiao R]]
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[[Category: Apoptosis]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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Current revision

Solution NMR Structure of CASP8-associated protein 2 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8150A

PDB ID 2lr8

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