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Ribosomal protein L2

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[[Image:RPL2.png|left|200px|thumb|Crystal Structure of Ribosomal protein L2 from ''Thermus thermophilus'' ([[2xg0]], chain D)]]
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<StructureSection load='1rl2' size='350' side='right' caption='Se-Met structure of ribosomal protein L2 [[1rl2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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{{STRUCTURE_2xg0| PDB=2xg0 | SIZE=400| SCENE=Ribosomal_protein_L2/Cv/1 |right|CAPTION=Ribosomal protein L2 from ''Thermus thermophilus'' [[2xg0]], chain D }}
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[[Ribosomal protein L2]] (RPL2) is one of the 34 proteins which belong to the <scene name='Ribosomal_protein_L2/Cv/2'>large 50S subunit</scene> of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is required for the association of the 30S and 50S subunits and is involved in the binding of tRNA at the A- and P-sites. In the archaea like in ''Haloarcula marismortui'', the L2 is called L2P (RPL2P). The images at the left and at the right correspond to one representative RPL2, ''i.e.'' the crystal structure of Ribosomal protein L2 from ''Thermus thermophilus'' ([[2xg0]], chain D).
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[[Ribosomal protein L2]] (RPL2) is one of the 34 proteins which belong to the <scene name='Ribosomal_protein_L2/Cv/2'>large 50S subunit</scene> of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is required for the association of the 30S and 50S subunits and is involved in the binding of tRNA at the A- and P-sites<ref>PMID:20097853</ref>. In the archaea like in ''Haloarcula marismortui'', the L2 is called L2P (RPL2P). The structure of the RNA-binding domain of L2 from ''Bacillus stearothermophilus'' is shown on the right<ref>PMID:10075918</ref>.
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{{TOC limit|limit=2}}
 
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</StructureSection>
== 3D Structures of Ribosomal protein L2 ==
== 3D Structures of Ribosomal protein L2 ==
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''Update June 2012''
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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=== RPL2 ===
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*Ribosomal protein L2
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**[[1rl2]] – RPL2 (mutant) – ''Geobacillus stearothermophilus''
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[[1rl2]] – RPL2 – ''Geobacillus stearothermophilus''
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*Ribosomal protein L2 in part of the large ribosomal subunit
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=== L2 in 50S subunit+RNA ===
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[[2xg0]], [[2xg2]], [[3kir]], [[3kit]], [[3kiw]], [[3kiy]] – TtRPL2 in 50S subunit+RNA fragments – ''Thermus thermophilus''<br />
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[[2x9s]], [[2x9u]], [[3kni]], [[3knk]], [[3knm]], [[3kno]], [[2wrj]], [[2wrl]], [[2wro]], [[2wrr]], [[3hux]], [[3huz]], [[2wh2]], [[2wh4]], [[2wdi]], [[2wdj]], [[2wdl]], [[2wdn]], [[1vsp]], [[2v47]], [[2v49]], [[1vsa]], [[2hgj]], [[2hgq]], [[2hgu]], [[2j01]], [[2j03]], [[1yl3]], [[3mrz]], [[3ms1]], [[3i8f]], [[3i8i]], [[3i9c]], [[3i9e]], [[3f1f]], [[3f1h]], [[3d5b]], [[3d5d]], [[2b66]], [[2b9n]], [[2b9p]], [[1giy]], [[2y0v]], [[2y0x]], [[2y0z]], [[2y11]], [[2y13]], [[2y15]], [[2y17]], [[2y19]], [[3pyo]], [[3pyr]], [[3pyt]], [[3pyv]], [[3tve]], [[3tvh]], [[3uye]], [[3uyg]], [[3uz1]], [[3uz2]], [[3uz8]], [[3uz9]], [[3uzf]], [[3uzh]], [[3uzk]], [[3uzn]], [[4dha]], [[4dhc]] - TtRPL2 in 50S subunit+5S RRNA+23S RRNA<br />
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[[3fin]] - TtRPL2 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM<br />
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[[2wwq]] – EcRPL2 in 50S subunit+5S RRNA+23S RRNA+mRNA+P-site tRNA – ''Escherichia coli''
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<br />
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[[3i1n]], [[3i1p]], [[3i1r]], [[3i1t]], [[3i20]], [[3i22]], [[3e1b]], [[3e1d]], [[3df2]], [[3df4]], [[2vhn]], [[2qov]], [[2qox]], [[2i2t]], [[2i2v]], [[1vs6]], [[1vs8]], [[2aw4]], [[2awb]], [[3ofd]], [[3og0]], [[1vor]], [[1vou]], [[1vow]], [[1voy]], [[1pnu]], [[1pny]],[[3r8s]], [[3r8t]], [[3uos]], [[3uxq]], [[3uxr]]- EcRPL2 in 50S subunit+5S RRNA+23S RRNA<br />
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[[3fik]], [[2gya]], [[2gyc]], [[3bbx]], [[1p85]], [[1p86]], [[3izt]], [[3izu]], [[3j0t]], [[3j0w]], [[3j0y]], [[3j11]], [[3j12]], [[3j14]], [[3j19]] - EcRPL2 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM<br />
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[[3kcr]] - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase<br />
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[[3j01]] - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase –Cryo-EM<br />
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[[2rdo]] - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+EF-G+RRF – Cryo-EM<br />
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[[3bbo]] - RPL2 in 50S subunit+5S RRNA+23S RRNA+4.8S RRNA – Cryo-EM – spinach<br />
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[[3iy9]] – RPL2 in 50S subunit – ''Leishmania taretolae''<br />
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[[2zjq]], [[2zjr]], [[1nkw]] - DrRPL2 in 50S subunit+5S RRNA+23S RRNA – ''Deinococcus radiodurans''<br />
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[[1kqs]], [[1qvg]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+CCA - ''Haloarcula marismortui''<br />
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[[1jj2]], [[1ffk]], [[3cc2]], [[2qa4]], [[1s72]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA<br />
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[[3cc7]], [[3cce]], [[3ccj]], [[3ccl]], [[3ccm]], [[3ccq]], [[3ccr]], [[3ccs]], [[3ccu]], [[3ccv]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA (mutant)<br />
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[[1vq4]], [[1vq5]], [[1vq7]], [[1vql]], [[1vqm]], [[1vqp]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+transition state analog<br />
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[[1vq6]], [[1vqk]], [[1vqn]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+ c-hpmn+CCA-Phe-caproic acid-biotin<br />
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[[1vqo]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+ CCPMN<br />
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[[1yhq]], [[1yi2]], [[1yij]], [[1yjn]], [[1yjw]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA (mutant)+antibiotic<br />
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[[1yj9]] - HmRPL2P in 50S subunit (L22 mutant)+5S RRNA+23S RRNA<br />
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[[1qvf]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA + deacylated tRNA minihelix<br />
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[[1q86]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+CCA-Phe-caproic acid-biotin<br />
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=== L2 in 50S subunit + antibiotics ===
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[[3dll]], [[2zjp]], [[3cf5]], [[1xbp]], [[1sm1]], [[1nwx]], [[1nwy]], [[3pio]], [[3pip]] - DrRPL2 in 50S subunit+5S RRNA+23S RRNA+antibiotic<br />
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[[3oh5]], [[3oh7]], [[3ohj]], [[3ohk]], [[3ohz]], [[3oi1]], [[3oi3]], [[3oi5]] - TtRPL2 in 50S subunit+5S RRNA+23S RRNA+antibiotic<br />
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[[2qam]], [[2qao]], [[2qoz]], [[2qp1]], [[2qba]], [[2qbc]], [[3ofc]], [[3ofz]], [[3ofq]], [[3ofr]], [[1vt2]], [[3orb]], [[3oas]], [[3oat]] - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+antibiotic<br />
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[[1k73]], [[1kc8]], [[1k8a]], [[1k9m]], [[1kd1]], [[1m1k]], [[3i55]], [[3i56]], [[3g4s]], [[3g6e]], [[3g71]], [[2qex]], [[3cpw]], [[3cc4]], [[3cd6]], [[2otj]], [[2otl]], [[1yit]], [[1q7y]], [[1q81]], [[1q82]], [[1n8r]], [[1nji]], [[3cxc]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+antibiotics <br />
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[[1m90]], [[3cma]], [[3cme]], [[1vq8]], [[1vq9]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+ sparsomycin+CCA-Phe-caproic acid-biotin
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=== L2 in 60S subunit ===
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[[3jyw]] - RPL2 in 60S subunit – ''Thermomyces lanuginosus'' – Cryo-EM<br />
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[[3izr]] - RPL2 in 60S subunit – wheat – Cryo-EM<br />
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[[2ftc]] - RPL2 in 60S subunit+16S RRNA - bovine<br />
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[[1s1i]] - yRPL2 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast<br />
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[[3o58]], [[3o5h]] - yRPL2 in 60S subunit+25S RRNA+5SRRNA+5.8RRNA
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=== L2 in part of the large ribosomal subunit ===
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[[487d]] – RPL2+RPL1+RPL6+RPL9+RPL11+RPL14+RPL25 - Cryo-EM<br />
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[[1c04]] – HmRPL2P+RPL6+RPL11+RPS14+23S RRNA fragment
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=== L2 in large + small ribosomal subunit ===
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[[1ml5]] - EcRPL2 in 50S ribosomal subunit+30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA – EM
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=== L2 in 50S subunit + ribosome releasing factor (RRF) ===
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[[2qbe]], [[2qbg]], [[2qbi]], [[2qbk]], [[2z4l]], [[2z4n]] - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+RRF
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=== L2 in 50S subunit + various proteins ===
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[[2vhm]] - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+PDF C-terminal helix<br />
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[[2j28]] - EcRPL2 in 50S subunit+5S RRNA+23S RRNA+signal recognition particle – Cryo-EM<br />
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[[1w2b]] - HmRPL2P in 50S subunit+5S RRNA+23S RRNA+trigger factor N-terminal
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**[[487d]] – RPL2+RPL1+RPL6+RPL9+RPL11+RPL14+RPL25 - ''Thermus thermophilus'' - Cryo-EM<br />
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**[[1c04]] – HmRPL2P+RPL6+RPL11+RPS14+23S RRNA fragment - ''Haloarcula marismortui''<br />
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Se-Met structure of ribosomal protein L2 1rl2, resolution 2.30Å

Drag the structure with the mouse to rotate

3D Structures of Ribosomal protein L2

Updated on 27-February-2022

References

  1. ↑ Rippa V, Cirulli C, Di Palo B, Doti N, Amoresano A, Duilio A. The ribosomal protein L2 interacts with the RNA polymerase alpha subunit and acts as a transcription modulator in Escherichia coli. J Bacteriol. 2010 Apr;192(7):1882-9. doi: 10.1128/JB.01503-09. Epub 2010 Jan 22. PMID:20097853 doi:http://dx.doi.org/10.1128/JB.01503-09
  2. ↑ Nakagawa A, Nakashima T, Taniguchi M, Hosaka H, Kimura M, Tanaka I. The three-dimensional structure of the RNA-binding domain of ribosomal protein L2; a protein at the peptidyl transferase center of the ribosome. EMBO J. 1999 Mar 15;18(6):1459-67. PMID:10075918 doi:10.1093/emboj/18.6.1459

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