Ribosomal protein L4

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[[Image:RPL4.png|left|200px|thumb|Crystal Structure of Ribosomal protein L4 from ''Thermus thermophilus'' ([[2xg0]], chain F)]]
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<StructureSection load='1dmg' size='350' side='right' scene='' caption='Ribosomal protein L4 complex with citric acid (PDB code [[1dmg]])'>
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{{STRUCTURE_2xg0| PDB=2xg0 | SIZE=400| SCENE=Ribosomal_protein_L4/Cv/1 |right|CAPTION=Ribosomal protein L4 from ''Thermus thermophilus'' [[2xg0]], chain F }}
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[[Ribosomal protein L4]] (RPL4 )<ref>PMID:10698923</ref> is one of the 34 proteins which belong to the <scene name='Ribosomal_protein_L4/Cv/2'>large 50S subunit</scene> of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It may actively participate in the catalysis of peptide bond formation<ref>PMID:6996835</ref>.. In the archaea like in ''Haloarcula marismortui'' the L4 is called L4P (RPL4P).
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</StructureSection>
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[[Ribosomal protein L4]] (RPL4 ) is one of the 34 proteins which belong to the <scene name='Ribosomal_protein_L4/Cv/2'>large 50S subunit</scene> of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It may actively participate in the catalysis of peptide bond formation. In the archaea like in Haloarcula marismortui the L4 is called L4P (RPL4P). The images at the left and at the right correspond to one representative RPL4, ''i.e.'' the crystal structure of Ribosomal protein L4 from ''Thermus thermophilus'' ([[2xg0]], chain F).
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{{TOC limit|limit=2}}
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== 3D Structures of Ribosomal protein L4 ==
== 3D Structures of Ribosomal protein L4 ==
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''Update June 2012''
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Updated on {{REVISIONDAY2}}/{{REVISIONMONTH}}/{{REVISIONYEAR}}
=== RPL4 ===
=== RPL4 ===
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[[1dmg]] – RPL4 – ''Thermotoga maritima''
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[[1dmg]] – RPL4 – ''Thermotoga maritima''<br />
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[[1j5a]], [[1jzx]], [[1jzy]], [[1jzz]], [[1k01]] – RPL4 + RPL22 + RPL32 + 23S RRNA + antibiotic – ''Deinococcus radiodurans''<br />
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=== L4 in 50S subunit+RNA ===
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[[5tqb]] – RPL4 + ACL4 – ''Chaetonium thermophilum''<br />
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[[2xg0]], [[2xg2]], [[3kir]], [[3kit]], [[3kiw]], [[3kiy]] – TtRPL4 in 50S subunit+RNA fragments – ''Thermus thermophilus''<br />
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[[2x9s]], [[2x9u]], [[3kni]], [[3knk]], [[3knm]], [[3kno]], [[2wrj]], [[2wrl]], [[2wro]], [[2wrr]], [[3hux]], [[3huz]], [[2wh2]], [[2wh4]], [[2wdi]], [[2wdj]], [[2wdl]], [[2wdn]], [[1vsp]], [[2v47]], [[2v49]], [[1vsa]], [[2hgj]], [[2hgq]], [[2hgu]], [[2j01]], [[2j03]], [[1yl3]], [[3mrz]], [[3ms1]], [[3i8f]], [[3i8i]], [[3i9c]], [[3i9e]], [[3f1f]], [[3f1h]], [[3d5b]], [[3d5d]], [[2b66]], [[2b9n]], [[2b9p]], [[1giy]], [[2y0v]], [[2y0x]], [[2y0z]], [[2y11]], [[2y13]], [[2y15]], [[2y17]], [[2y19]], [[3pyo]], [[3pyr]], [[3pyt]], [[3pyv]], [[3tve]], [[3tvh]], [[3uye]], [[3uyg]], [[3uz1]], [[3uz2]], [[3uz8]], [[3uz9]], [[3uzf]], [[3uzh]], [[3uzk]], [[3uzn]], [[4dha]], [[4dhc]] - TtRPL4 in 50S subunit+5S RRNA+23S RRNA<br />
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[[3fin]] - TtRPL4 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM<br />
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[[2wwq]] – EcRPL4 in 50S subunit+5S RRNA+23S RRNA+mRNA+P-site tRNA – ''Escherichia coli''<br />
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[[3i1n]], [[3i1p]], [[3i1r]], [[3i1t]], [[3i20]], [[3i22]], [[3e1b]], [[3e1d]], [[3df2]], [[3df4]], [[2vhn]], [[2qov]], [[2qox]], [[2i2t]], [[2i2v]], [[1vs6]], [[1vs8]], [[2aw4]], [[2awb]], [[3ofd]], [[3og0]], [[1vor]] [[1vou]], [[1vow]], [[1voy]], [[1vp0]], [[1pnu]], [[1pny]], [[3r8s]], [[3r8t]] [[3uos]], [[3uxq]], [[3uxr]] - EcRPL4 in 50S subunit+5S RRNA+23S RRNA<br />
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[[3fik]], [[2gya]], [[2gyc]], [[3bbx]], [[1p85]], [[1p86]], [[3izt]], [[3izu]], [[3j0t]], [[3j0w]], [[3j0y]], [[3j11]], [[3j12]], [[3j14]], [[3j19]] - EcRPL4 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM<br />
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[[3kcr]] - EcRPL4 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase<br />
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[[3j01]] – EcRPL4 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase – Cryo-EM<br />
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[[2rdo]] - EcRPL4 in 50S subunit+5S RRNA+23S RRNA+EF-G+RRF – Cryo-EM<br />
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[[3bbo]] – RPL4 in 50S subunit+5S RRNA+23S RRNA+4.8S RRNA – Cryo-EM – spinach<br />
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[[3iy9]] – RPL4 in 50S subunit – ''Leishmania taretolae''<br />
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[[2zjq]], [[2zjr]], [[1nkw]] - DrRPL4 in 50S subunit+5S RRNA+23S RRNA – ''Deinococcus radiodurans''<br />
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[[1kqs]] - HmRPL4P in 50S subunit+5S RRNA+23S RRNA+CCA - ''Haloarcula marismortui''<br />
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[[1jj2]], [[1ffk]], [[3cc2]], [[2qa4]] - HmRPL4P in 50S subunit+5S RRNA+23S RRNA<br />
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[[3cc7]], [[3cce]], [[3ccj]], [[3ccl]], [[3ccm]], [[3ccq]], [[3ccr]], [[3ccs]], [[3ccu]], [[3ccv]] - HmRPL4P in 50S subunit+5S RRNA+23S RRNA (mutant)<br />
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=== L4 in 50S subunit + antibiotics ===
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[[3dll]], [[2zjp]], [[3cf5]], [[1xbp]], [[1sm1]], [[1nwx]], [[1nwy]], [[3pio]], [[3pip]] - DrRPL4 in 50S subunit+5S RRNA+23S RRNA+antibiotic <br />
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[[3oh5]], [[3oh7]], [[3ohj]], [[3ohk]], [[3ohz]], [[3oi1]], [[3oi3]], [[3oi5]] – TtRPL4 in 50S subunit+5S RRNA+23S RRNA+antibiotic<br />
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[[2qam]], [[2qao]], [[2qoz]], [[2qp1]], [[2qba]], [[2qbc]], [[3ofc]], [[3ofz]], [[3ofq]], [[3ofr]], [[1vt2]], [[3orb]], [[3oas]], [[3oat]] - EcRPL4 in 50S subunit+5S RRNA+23S RRNA+antibiotic<br />
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[[1k73]], [[1kc8]], [[1k8a]], [[1k9m]], [[1kd1]], [[1m1k]], [[3i55]], [[3i56]], [[3g4s]], [[3g6e]], [[3g71]], [[2qex]], [[3cpw]],[[3cc4]], [[3cd6]], [[2otj]], [[2otl]], [[3cxc]] - HmRPL4P in 50S subunit+5S RRNA+23S RRNA+antibiotic - ''Halobacterium marismortui''<br />
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[[1m90]], [[3cma]], [[3cme]] - HmRPL4P in 50S subunit+5S RRNA+23S RRNA+ sparsomycin+CCA-Phe-caproic acid-biotin<br />
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[[1jzx]], [[1jzy]], [[1jzz]], [[1j5a]], [[1k01]] - DrRPL4+RPL22+RPL42+23S RRNA+antibiotic<br />
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=== L4 in 60S subunit ===
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[[3jyw]] - RPL4 in 60S subunit – ''Thermomyces lanuginosus'' – Cryo-EM<br />
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[[2ftc]] - RPL4 in 60S subunit+16S RRNA - bovine<br />
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[[1s1i]] - yRPL4 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast<br />
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[[3izs]] – yRPL4 in 60S ribosomal subunit – Cryo-EM<br />
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[[3u5e]], 3u5i]] – yRPL4 in 60S ribosomal subunit<br />
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[[3o58]], [[3o5h]] – yRPL4 in 60S subunit+25S RRNA+5SRRNA+5.8RRNA<br />
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[[2ww9]], [[2wwa]], [[2wwb]] – yRPL4+RPL17+RPL19+RPL15+RPL25+RPL26+RPL41+RPL45+RPL49+25S RRNA+SSH1P+SSS1+SEB2<br />
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[[4a1a]], [[4a1c]], [[4a1e]] – RPL4 in 60S subunit+5SRRNA+5.8RRNA – ''Tetrahymna thermophila''
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=== L4 in large + small ribosomal subunit ===
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[[1ml5]] - EcRPL4 in 50S ribosomal subunit+30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA – EM<br />
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[[2zkr]] - RPL4 in 60S ribosomal subunit+30S ribosomal subunit+28S RRNA+5.8S RRNA – Cryo-EM - dog
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=== L4 in 50S subunit + ribosome releasing factor (RRF) ===
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[[2qbe]], [[2qbg]], [[2qbi]], [[2qbk]], [[2z4l]], [[2z4n]] - EcRPL4 in 50S subunit+5S RRNA+23S RRNA+RRF
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=== L4 in 50S subunit + various proteins ===
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[[2vhm]] - EcRPL4 in 50S subunit+5S RRNA+23S RRNA+PDF C-terminal helix<br />
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[[2j28]] - EcRPL4 in 50S subunit+5S RRNA+23S RRNA+signal recognition particle – Cryo-EM<br />
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[[1w2b]] - HmRPL4P in 50S subunit+5S RRNA+23S RRNA+trigger factor N-terminal
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Ribosomal protein L4 complex with citric acid (PDB code 1dmg)

Drag the structure with the mouse to rotate

3D Structures of Ribosomal protein L4

Updated on 27/2/2022

RPL4

1dmg – RPL4 – Thermotoga maritima
1j5a, 1jzx, 1jzy, 1jzz, 1k01 – RPL4 + RPL22 + RPL32 + 23S RRNA + antibiotic – Deinococcus radiodurans
5tqb – RPL4 + ACL4 – Chaetonium thermophilum

References

  1. ↑ Worbs M, Huber R, Wahl MC. Crystal structure of ribosomal protein L4 shows RNA-binding sites for ribosome incorporation and feedback control of the S10 operon. EMBO J. 2000 Mar 1;19(5):807-18. PMID:10698923 doi:http://dx.doi.org/10.1093/emboj/19.5.807
  2. ↑ Yates JL, Nomura M. E. coli ribosomal protein L4 is a feedback regulatory protein. Cell. 1980 Sep;21(2):517-22. PMID:6996835

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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