Ribosomal protein S6

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[[Image:RPS6.png|left|200px|thumb|Crystal Structure of Ribosomal protein S6 from [[2zm6]], chain F]]
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<StructureSection load='2bvz' size='350' side='right' scene='' caption='Ribosomal protein S6 (PDB code [[2bvz]])'>
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{{STRUCTURE_2zm6| PDB=2zm6 | SIZE=400| SCENE=Ribosomal_protein_S6/Cv/1 |right|CAPTION=Ribosomal protein S6 from [[2zm6]], chain F }}
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[[Ribosomal protein S6]] (RPS6) is one of the 21 proteins which belong to the 30S <scene name='Ribosomal_protein_S6/Cv/2'>small subunit</scene> of the [http://en.wikipedia.org/wiki/Bacteria bacterial] [[ribosome]] or the 30 proteins which belong to the 40S small subunit of the eukaryotic ribosome. It has a role in regulating translation of RNAs that contain the 5' terminal sequence<ref>PMID:16679021</ref>. It is regulated by ribosomal S6 kinase.
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</StructureSection>
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[[Ribosomal protein S6]] (RPS6) is one of the 22 proteins which belong to the <scene name='Ribosomal_protein_S6/Cv/2'>small subunit</scene> of the [http://en.wikipedia.org/wiki/Bacteria bacterial] [[ribosome]]. It has a role in regulating translation of RNAs that contain the 5' terminal sequence. It is regulated by ribosomal S6 kinase.
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The images at the left and at the right correspond to one representative RPS6, ''i.e.'' the crystal structure of Ribosomal protein S6 from ''Thermus thermophilus'' ([[2zm6]], chain F).
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{{TOC limit|limit=2}}
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<br />
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<br />
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== 3D Structures of Ribosomal protein S6 ==
== 3D Structures of Ribosomal protein S6 ==
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''Update December 2011''
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===RPS6===
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[[2kjv]] – TtRPS6 – NMR - ''Thermus thermophilus''<br />
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[[2kjw]] – TtRPS6 (mutant)– NMR<br />
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[[2bvz]], [[1ris]] – TtRPS6<br />
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[[2bxj]], [[1cqm]], [[1cqn]], [[1qjh]], [[1lou]] - TtRPS6 (mutant)<br />
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[[2j5a]] – RPS6 – ''Aquifex aeolicus''<br />
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[[1vmb]] – RPS6 – ''Thermotoga maritima''<br />
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[[3r3t]] – RPS6 – ''Bacillus anthracis''
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===S6 in small ribosomal subunit===
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[[2zm6]], [[1n36]], [[1j5e]], [[3oge]], [[3ogy]], [[3ohc]], [[3ohd]], [[3ohy]], [[3oi0]], [[3oi2]], [[3oi4]], [[3oto]] - TtRPS6 in 30S ribosomal subunit+THX+16S RRNA<br />
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[[2vqe]], [[2vqf]], [[2uuc]], [[2e5l]], [[2uu9]], [[2uua]], [[2uub]], [[3pyn]], [[3pyq]], [[3pys]], [[3pyu]] - TtRPS6 in 30S ribosomal subunit+16S RRNA+RNA fragment<br />
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[[3kc4]] – EcRPS6 in 30S ribosomal subunit - ''Escherichia coli''<br />
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[[3i1m]], [[3i1o]], [[3df1]], [[3df3]], [[2vho]], [[2vhp]], [[2avy]], [[2aw7]], [[1pnx]], [[1oaq]], [[3oar]], [[3ofa]], [[3ofb]], [[2ofo]], [[3ofp]], [[3ofx]], [[3ofy]], [[3or9]], [[3ora]] - EcRPS6 in 30S ribosomal subunit+16S RRNA<br />
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[[1i94]], [[1fka]] - TtRPS6 in 30S ribosomal subunit+16S RRNA<br />
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[[1p87]], [[1p6g]] - EcRPS6 in 30S ribosomal subunit+16S RRNA – Cryo-EM<br />
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[[3bbn]] - RPS6 in 30S ribosomal subunit+16S RRNA – Cryo-EM – spinach
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===S6 in small + large ribosomal subunit===
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[[1ml5]] - EcRPS6 in 30S ribosomal subunit+50S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA - EM
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===S6 in small ribosomal subunit+ chain release factor===
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[[3mr8]], [[3ms0]] – TtRPS6 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+mRNA+16S RRNA<br />
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[[3d5a]], [[3d5c]] - TtRPS6 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
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[[3zvo]] – TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA Met +mRNA +16S RRNA+chain release factor 3<br />
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[[2b64]] - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 1<br />
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[[2b9m]] - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 2<br />
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[[2x9r]], [[2x9t]], [[2wh1]], [[2wh3]] - TtRPS6 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+mRNA +16S RRNA<br />
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[[3f1e]], [[3f1g]] - TtRPS6 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+E-site tRNA +16S RRNA
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===S6 in small ribosomal subunit+tRNA+mRNA===
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[[2hgi]] - TtRPS6 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet<br />
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[[2hgp]] - TtRPS6 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA<br />
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[[2i2p]], [[2i2u]] - EcRPS6 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA<br />
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[[2hgr]] - TtRPS6 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet+mRNA<br />
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[[1yl4]] – TtRPS6 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+THRS mRNA operator<br />
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[[1pns]] - EcRPS6 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+mRNA <br />
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[[1xnq]], [[1xnr]] - TtRPS6 in 30S ribosomal subunit+THX+mRNA+tRNA anticodon+16S RRNA
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===S6 in small ribosomal subunit+A-site tRNA===
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[[2uxd]] , [[2uxc]] - TtRPS6 in 30S ribosomal subunit+THX+A-site mRNA CGGG+tRNA anticodon+16S RRNA<br />
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[[1n32]], [[1n33]] - TtRPS6 in 30S ribosomal subunit+THX+A-site mRNA fragment+tRNA anticodon+16S RRNA<br />
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[[1n34]] - TtRPS6 in 30S ribosomal subunit+THX+A-site mRNA fragment +16S RRNA<br />
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[[1xmo]], [[1xmq]] - TtRPS6 in 30S ribosomal subunit+THX+A-site mRNA+tRNA anticodon+16S RRNA<br />
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[[2uxb]] - TtRPS6 in 30S ribosomal subunit+THX+A-site mRNA GGGU+tRNA anticodon+16S RRNA
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===S6 in small ribosomal subunit+P-site tRNA===
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[[3i8g]] - TtRPS6 in 30S ribosomal subunit+P-site tRNA+mRNA +16S RRNA<br />
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[[3i8h]], [[3i9b]], [[3i9d]] - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA<br />
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[[1ibk]] - TtRPS6 in 30S ribosomal subunit+THX+P-site mRNA fragment +16S RRNA<br />
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[[2wwl]] - EcRPS6 in 30S ribosomal subunit+Poly-Ala chain+P-site tRNA+mRNA +16S RRNA - ''Escherichia coli''<br />
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[[3i1q]] - EcRPS6 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA <br />
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[[3i1s]], [[3i1z]], [[3i21]] - EcRPS6 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA +16S RNA
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===S6 in small ribosomal subunit+A-site tRNA+P-site tRNA===
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[[1ibl]], [[1ibm]] - TtRPS6 in 30S ribosomal subunit+THX+A-site mRNA fragment+P-site mRNA fragment+tRNA anticodon+16S RRNA
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===S6 in small ribosomal subunit+P-site tRNA+E-site tRNA===
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[[2ow8]] - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA+mRNA +16S RRNA<br />
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[[2b9o]] - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA<br />
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[[2qnh]] - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
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[[2wdg]], [[2wdh]], [[2wdk]], [[2wdm]] - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA+tRNA Phe
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===S6 in small ribosomal subunit+A-site tRNA+P-site tRNA+E-site tRNA===
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[[2gy9]], [[2gyb]] - EcRPS6 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA – Cryo-EM<br />
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[[1jgo]], [[1jgp]], [[1jgq]], [[1gix]] - TtRPS6 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+tRNA Phe+mRNA +16S RRNA<br />
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[[3e1a]], [[3e1c]] - EcRPS6 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA
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===S6 in small ribosomal subunit + antibiotics===
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[[1i95]], [[1i97]], [[2hhh]], [[2f4v]], [[3knn]] - TtRPS6 in 30S ribosomal subunit+16S RRNA+antibiotic<br />
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[[1hnw]], [[1hnx]], [[1hnz]], [[1fjg]] - TtRPS6 in 30S ribosomal subunit+16S RRNA+mRNA fragment+antibiotic<br />
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[[2qbb]], [[2qb9]], [[1vs5]], [[1vs7]], [[2qan]], [[2qal]], [[2qou]], [[2qow]], [[2qoy]], [[2qp0]], [[2z4k]], [[2z4m]], [[3oaq]], [[3ofo]] - EcRPS6 in 30S ribosomal subunit+16S RRNA+antibiotic<br />
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[[2j00]], [[2j02]] - TtRPS6 in 30S ribosomal subunit+16S RRNA+paromomycin+P-site tRNA fMet+E-site tRNA Phe+mRNA<br />
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[[3knj]], [[3knh]] - TtRPS6 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+viomycin<br />
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[[3knl]], [[3knm]] - TtRPS6 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+capreomycin
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===S6 in small ribosomal subunit + ribosome recycling factor===
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[[2qbd]], [[2qbf]] - EcRPS6 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor<br />
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[[3r8n]], [[3r8o]] – EcRPS6 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor + mRNA + tRNA<br />
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[[2qbh]], [[2qbj]] - EcRPS6 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+gentamicin<br />
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[[2v46]], [[2v48]] - TtRPS6 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+P-site tRNA Phe+mRNA+tRNA fMet
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===S6 in small ribosomal subunit + elongation factor===
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[[2wri]], [[2wrk]], [[2xsy]], [[2xuy]] - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA+elongation factor G<br />
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[[2wrn]], [[2wrq]] - TtRPS6 in 30S ribosomal subunit+THX+A-site tRNA+mRNA +16S RRNA+elongation factor TU-4<br />
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[[3fic]] - TtRPS6 in 30S ribosomal subunit+THX+A-site tRNA+P-site tRNA+E-site tRNA+mRNA codon+16S RRNA+elongation factor TU-A<br />
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[[3izv]] – EcRPS6 in 30S ribosomal subunit+A/T-site tRNA Phe +16S RRNA+elongation factor TU<br />
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[[3izw]] – EcRPS6 in 30S ribosomal subunit+A-site tRNA Phe +mRNA +16S RRNA+elongation factor TU<br />
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[[2y0u]], [[2y0w]], [[2y0y]], [[2y10]], [[2y12]], [[2y14]], [[2y16]], [[2y18]] - TtRPS6 in 30S subunit+THX+A-site tRNA+E-site tRNA+mRNA codon+elongation factor TU<br />
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[[3fih]] - EcRPS6 in 30S ribosomal subunit+A-site tRNA Phe+P-site tRNA+mRNA +16S RRNA+elongation factor TU<br />
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[[3huw]], [[3huy]] - TtRPS6 in 30S ribosomal subunit+THX+tRNA-Met+mRNA +16S RRNA+elongation factor P<br />
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[[2xqd]] – TtRPS6 in 30S ribosomal subunit+THX+E-site tRNA+mRNA +16S RRNA+elongation factor TU-B<br />
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===S6 in small ribosomal subunit + translation initiation factor===
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[[1i96]] - TtRPS6 in 30S ribosomal subunit+THX+IF3+16S RRNA<br />
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[[1hr0]] - TtRPS6 in 30S ribosomal subunit+THX+IF+16S RRNA
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===S6 in small ribosomal subunit + various proteins===
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[[3kiq]], [[3kis]], [[3kiu]], [[3kix]] - TtRPS6 in 30S ribosomal subunit+toxin RelE+16S RRNA<br />
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*Ribosomal protein S6
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[[1voq]], [[1vos]] , [[1vov]], [[1vox]], [[1voz]] - EcRPS6 in 30S ribosomal subunit+protein Y+16S RRNA<br />
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[[3iy8]] – EcRPS6+EcRPS5+EcRPS8+EcRPS9+EcRPS11+EcRPS12+EcRPS15+EcRPS16+EcRPS17+EcRPS18+Leishmania taretolae small subunit<br />
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[[2xfz]], [[2xg1]] – TtRPS6 in 30S ribosomal subunit+colicin E3+E-site tRNA+mRNA+16S RRNA<br />
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[[3j00]] – EcRPS6 + 16S RRNA + FTSQ + apolipoprotein A-I<br />
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[[2ykr]] – EcRPS6 + 16S RRNA + GMPPNP + GTPase RSGA<br />
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[[4a2i]] – EcRPS6 + 16S RRNA + GTPase RSGA – Cryo EM
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===S6 in part of small ribosomal subunit===
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**[[2kjv]] – TtRPS6 – NMR - ''Thermus thermophilus''<br />
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**[[2kjw]] – TtRPS6 (mutant) – NMR<br />
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**[[2bvz]], [[1ris]], [[3zzp]] – TtRPS6<br />
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**[[2bxj]], [[1cqm]], [[1cqn]], [[1qjh]], [[1lou]] - TtRPS6 (mutant)<br />
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[[6i6w]], [[6i6y]], [[7b8v]] – TtRPS6 circular permutation<br />
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[[6i69]], [[6i6e]], [[6i6i]], [[6i6o]], [[6i6s]], [[6i6u]] – TtRPS6 (mutant) circular permutation<br />
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**[[2j5a]] – RPS6 – ''Aquifex aeolicus''<br />
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**[[1vmb]] – RPS6 – ''Thermotoga maritima''<br />
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**[[3r3t]] – RPS6 – ''Bacillus anthracis''
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[[1qd7]] – TtRPS6+TtRPS4+TtRPS5+TtRPS7+TtRPS8+TtRPS15+TtRPS17+TtRPS20+16S RRNA fragment<br />
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*Ribosomal protein S6 in part of small ribosomal subunit
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[[1g1x]] - TtRPS6+TtRPS15+TtRPS18+16S RRNA fragment
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**[[1qd7]] – TtRPS6+TtRPS4+TtRPS5+TtRPS7+TtRPS8+TtRPS15+TtRPS17+TtRPS20+16S RRNA fragment<br />
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**[[1g1x]] - TtRPS6+TtRPS15+TtRPS18+16S RRNA fragment<br />
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**[[3j16]] – yRPS6 + yRPS24 + yRPS30 + yRPL6 + yRPL10 + yRPL11 + 18S RRNA + 28SRRNA + P-site tRNA – yeast - Cryo EM
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Ribosomal protein S6 (PDB code 2bvz)

Drag the structure with the mouse to rotate

3D Structures of Ribosomal protein S6

Updated on 01-March-2022

6i6w, 6i6y, 7b8v – TtRPS6 circular permutation
6i69, 6i6e, 6i6i, 6i6o, 6i6s, 6i6u – TtRPS6 (mutant) circular permutation

References

  1. ↑ Ruvinsky I, Meyuhas O. Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Trends Biochem Sci. 2006 Jun;31(6):342-8. Epub 2006 May 6. PMID:16679021 doi:http://dx.doi.org/10.1016/j.tibs.2006.04.003

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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